1. Introduction: Retina Imaging – Past and Present
2. OCT Technique – Past, Present and Future
3. Optical Coherence Tomography and Optic Nerve Edema
4. OCT and Compressive Optic Neuropathy
5. Optical Coherence Tomography (OCT) and Multiple Sclerosis (MS)
6. OCT and Parkinson’s Disease
7. Optical Coherence Tomography in Alzheimer’s Disease
8. Friedreich’s Ataxia and More: Optical Coherence Tomography Findings in Rare Neurological Syndromes
9. Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS)
10. Hereditary Optic Neuropathies
11. Trans Neuronal Retrograde Degeneration to OCT in Central Nervous System Diseases
12. OCT in Toxic and Nutritional Optic Neuropathies
13. Animal Models in Neuro Ophthalmology
14. Optical Coherence Tomography (OCT) in Glaucoma
15. OCT in Amblyopia
16. Conclusion: The Exciting Future of OCT Imaging of Retina
This book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, intracranial hypertension, Friedreich’s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the “window to the brain”.
• Describes the role of OCT in evaluating disease progression in neurodegenerative disorders
• Covers a wide range of disorders
• Documents recent advances and explains their significance
• Andrzej Grzybowski, MD, PhD, is Professor of Ophthalmology and Chair of the Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland and Head of the Department of Ophthalmology at Poznan City Hospital, Poznan, Poland. His major areas of expertise are cataract surgery, presbyopia treatment, clear lens exchange, vitroretinal surgery, glaucoma pathogenesis, neuro-ophthalmology, and history of ophthalmology. Dr. Grzybowski is a member of the European University Professors of Ophthalmology (EUPO), an expert of the European Medicines Agency, an International Fellow of the American Academy of Ophthalmology, and an International Projects and Grants Reviewer for the College of Optometry, London. He is also acting as program coordinator for the World Congress of Ophthalmology in Tokyo in 2014. Dr. Grzybowski is the recipient of various awards, including the Bronze Cross of Merit from the President of Poland in 2008 and the Zakon Prize from the History of Dermatology Society in 2010 and 2011. He is involved in editorial work in collaboration with many prestigious journals, as associate editor (Acta Ophthalmologica), section editor (Clinics in Dermatology, Neuro-Ophthalmology), editor in chief (Archive of the History and Philosophy of Medicine), editorial board member (Saudi Journal of Ophthalmology), and reviewer (more than 20 journals). He is the author of more than 230 international peer-reviewed papers.
• Piero Barboni, MD, graduated in Medicine and Surgery from the University of Bologna, Italy, in 1986 and went on to complete his Specialization in Ophthalmology at the same university in 1990. After spending almost two decades in private practice, he was appointed Professor of Neuro-ophthalmology in the Department of Neurological Science, Bologna University. Since 2012 Dr. Barboni has been a Consultant Ophthalmologist at the Scientific Institute San Raffaele, University of Milan. His memberships include the Association for Research in Vision and Ophthalmology (ARVO) and the North American Neuro-Ophthalmology Society (NANOS). Dr. Barboni has been sub-investigator in many clinical trials on good clinical practice in multiple sclerosis and is a participant in an international research project on Leber’s hereditary optic neuropathy. He is the author of more than 70 articles in peer-reviewed journals.