OVARIAN CANCER: THE “GYNAECOLOGICAL CHALLENGE” FROM DIAGNOSTIC WORK-UP TO CYTOREDUCTION AND CHEMOTHERAPY. VOLUME 1

Preface
Chapter 1. Ovarian Cancer Pathology and Surgery, Historical Pearls from the Pioneering Greeks and the General Term Gynecologic Cancer to Modern Histopathology and Ovarian Malignancy
Chapter 2. Ovarian Cancer Screening
Chapter 3. The Role of Ultrasounds in the Diagnosis and Management of Adnexal Tumours
Chapter 4. Preoperative Biomarkers to Predict Resectability of Patients with Ovarian Cancer
Chapter 5. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) Findings in Ovarian Cancer
Chapter 6. The Role of 18FDG PET/CT Scans in Ovarian Cancer Patients
Chapter 7. The Pathogenesis of Ovarian Cancer
Chapter 8. Inherited Ovarian Cancer-Linked Syndromes and Management
Chapter 9. Pathology of Epithelial Ovarian Tumors
Chapter 10. Pathology of Non-Epithelial Ovarian Tumours
Chapter 11. The Role of Immunohistochemistry in Ovarian Tumours
Chapter 12. Molecular Pathology of Epithelial Ovarian Tumours
Chapter 13. An Approach to Borderline Ovarian Tumors
Chapter 14. Prophylactic Salpingo-Oophorectomy in High-Risk Patients
Chapter 15. The Management of Early-Stage Epithelial Ovarian Cancer
Chapter 16. Fertility Sparing in Ovarian Cancer Patients
Chapter 17. The Local-Regional Control of Ovarian Cancer
Chapter 18. Surgical Management of Advanced Epithelial Ovarian Cancer
Chapter 19. Primary Versus Interval Debulking Surgery in Ovarian Cancer Patients
Chapter 20. Lymphadenectomy in Ovarian Cancer Surgery
Chapter 21. Serous Papillary Primary Peritoneal Carcinoma
Chapter 22. Ovarian Carcinosarcoma
Chapter 23. Krukenberg Tumors
Chapter 24. Pseudomyxoma Peritonei
Chapter 25. Ovarian Malignancies During Pregnancy
Index

Ovarian cancer is one of the deadliest gynaecological cancers. In most cases, it is detected as an advanced tumor, since early diagnosis is challenging for most forms of the disease. Surgery and platinum-based compounds have been the mainstay of therapy for many years. The prognosis for ovarian cancer depends on the type of surgery and on the response to chemotherapy. Other regimens have little effect if the disease does not respond to platinum. However, several new therapies are emerging including bevacizumab and PARP-inhibitors, among others. This book provides a detailed body of information important to an understanding of the clinical aspects and management of such a challenging disease. The authors strive to provide the physician with insights and illustrations as well as useful tips and tricks for the everyday clinical practice.
Several world-known experts in the field participated in this fruitful effort offering their knowledge and everyday experience, as well as valuable and original photos from their personal archives as well as the most recent and up-to-date guidelines in the field.
In this book, we evaluate all the challenging pathways from the moment of diagnosis to the surgical and medical therapies. The pathogenesis, the variation of the morphological types and the problems in differential diagnosis are also discussed. Moreover, we provide an overview of recent attempts to improve the diagnosis and prognosis of ovarian cancer as well as a discussion of fertility sparing alternatives and minimal invasive (laparoscopic and robotic) approaches. All the new diagnostic and therapeutic strategies that lay out the foundation for these improvements are presented. Areas of future research are also discussed, supported by a wealth of up-to-date reference material. The book is written at a level appropriate for both medical students, physicians as well as gynaecological oncologists, pathologists, and medical oncologists.

Authors
• Christos Iavazzo – Metaxa Memorial Cancer Hospital, Piraeus, Greece
• Alexandros Fotiou, MD – Metaxa Memorial Cancer Hospital, Piraeus, Greece
• John Spiliotis, PhD – Department of Surgical Oncology and HIPEC, Athens Medical Centre, Athens, Greece; Department of Surgical Oncology and HIPEC, European Interbalkan Medical Centre, Thessaloniki, Greece