OXIDATIVE STRESS AND ANTIOXIDANT PROTECTION: THE SCIENCE OF FREE RADICAL BIOLOGY AND DISEASE

• Section 1: Introduction
1 Introduction to Free Radicals, Inflammation, and Recycling 3
2 Diagnostic Imaging and Differential Diagnosis 11
• Section 2: Clinical Correlations on Acute and Chronic Diseases
3 Free Radicals: Their Role in Brain Function and Dysfunction 23
4 Mediators of Neuroinflammation 39
5 Oxidative and Nitrative Stress in Schizophrenia 57
6 The Effects of Hypoxia, Hyperoxia, and Oxygen Fluctuations on Oxidative Signaling in the Preterm Infant and on Retinopathy of Prematurity 77
7 Oxidative Damage in the Retina 93
8 The Role of Oxidative Stress in Hearing Loss 115
9 Disorders of Children 133
10 Oxidative Stress in Oral Cavity: Interplay between Reactive Oxygen Species and Antioxidants in Health, Inflammation, and Cancer 155
11 Oxidative Stress and the Skin 167
12 Oxidative Stress in Osteoarticular Diseases 183
13 Gene Therapy to Reduce Joint Inflammation in Horses 193
14 Muscle and Oxidative Stress 205
15 Role of Oxidants and Antioxidants in Male Reproduction 221
16 Role of Oxidants and Antioxidants in Female Reproduction 253
17 Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Diseases 281
18 Oxidative Stress and Antioxidant Imbalance: Respiratory Disorders 307
19 Oxidative Stress and Type 1 Diabetes 319
20 Metabolic Syndrome, Inflammation, and Reactive Oxygen Species in Children and Adults, 329
21 Oxidative Stress in Chronic Pancreatitis 339
22 Wound Healing and Hyperbaric Oxygen Therapy Physiology: Oxidative Damage and Antioxidant Imbalance 347
23 Radiobiology and Radiotherapy 357
24 Chemotherapy-Mediated Pain and Peripheral Neuropathy: Impact of Oxidative Stress and Inflammation 367
25 Grape Polyphenol-rich Products with Antioxidant and Anti-inflammatory Properties 389
26 Isotonic Oligomeric Proanthocyanidins 403
27 Superoxide Dismutase Mimics and Other Redox-active Therapeutics 415
28 Herbal Medicine: Past, Present, and Future with Emphasis on the Use of Some Common Species 471
29 Ayurvedic Perspective on Oxidative Stress Management 483
30 Clinical Trials and Antioxidant Outcomes 493
31 Statistical Approaches to Make Decisions in Clinical Experiments 507
Index 561

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and< Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism.
Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology.
Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.