List of Contributors xvii
About the Companion Website xxv
1 Themes in Bacterial Pathogenesis 1
2 Evolution of Bacterial Pathogens 15
3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics 32
4 Experimental Approaches to Understanding Pathogenesis 57
5 Subversion of the Immune Response by Bacterial Pathogens 79
6 Chinks in the Armor 99
7 Escherichia coli 117
8 Salmonella 162
9 Yersinia 200
10 Pasteurella 221
11 Mannheimia and Bibersteinia 244
12 Actinobacillus 262
13 Other Pasteurellaceae: Avibacterium, Bibersteinia, Gallibacterium, Glaesserella, and
14 Pseudomonas 318
15 Moraxella 344
16 Brucella 361
17 Bordetella 376
18 Campylobacter 393
19 Helicobacter 413
20 Chlamydia and Coxiella 433
21 Rickettsiales 456
22 Lawsonia intracellularis 486
23 Leptospira 502
24 Brachyspira 528
25 Staphylococcus 543
26 Streptococcus 565
27 Bacillus anthracis 588
28 Enteric Clostridia 607
29 Histotoxic Clostridia 635
30 Neurotoxic Clostridia 648
31 Mycoplasmas 667
32 Corynebacterium, Arcanobacterium, and Trueperella 701
33 Rhodococcus equi 715
34 Mycobacterium 736
35 Gram-Negative Anaerobes 757
Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease
Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references.
This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context.
Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on:
• Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era
• Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity
• Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies
• Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity
Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.
• John F. Prescott is University Professor Emeritus at the University of Guelph, in Guelph, Ontario, Canada.
• John D. Boyce is Associate Professor at Monash Biomedicine Discovery Institute, Monash University, in Clayton, Victoria, Australia.
• Janet I. MacInnes is Professor Emerita at the University of Guelph in Guelph, Ontario, Canada.
• Andrew N. Rycroft is Professor at the Royal Veterinary College, in Hatfield, Hertfordshire, United Kingdom.
• Filip Van Immerseel is Professor at Ghent University in Merelbeke, Belgium.
• José A. Vázquez-Boland is Professor at the University of Edinburgh in Edinburgh, United Kingdom.