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I Biologic Aspects of Gastrointestinal Function
1. Development of the Gastrointestinal Tract
2. Basics Aspects of Digestion and Absorption
3. Bile Acid Physiology and Alterations in the Enterohepatic Circulation
4. The Gut Microbiome in Pediatrics
5. Gastrointestinal Mucosal Immunology and Mechanisms of Inflammation

II Clinical Problems
6. Chronic Abdominal Pain of Childhood and Adolescence
7. Approach to the Child with a Functional Gastrointestinal Disorder
8. Vomiting and Nausea
9. Diarrhea
10. Colic and Gastrointestinal Gas
11. Functional Constipation and Incontinence
12. Failure to Thrive
13. Gastrointestinal Hemorrhage
14. Obesity
15. Eating Disorders in Children and Adolescents
16. Jaundice: Unconjugated Hyperbilirubinemia
17. Ascities
18. Caustic Ingestion and Foreign Bodies

III The Esophagus
19. Developmental Anatomy and Physiology of the Esophagus
20. Congenital Malformations of the Esophagus
21. Gastroesophageal Reflux
22. Achalasia and Other Motor Disorders
23. Other Diseases of the Esophagus

IV The Stomach
24. Developmental Anatomy and Physiology of the Stomach
25. Congenital Anomalies and Surgical Disorders of the Stomach
26. Gastritis, Gastropathy, and Ulcer Disease
27. Helicobacter Pylori in Childhood
28. Gastric Motility Disorders
29. Bezoars

V The Small and Large Intestine
30. Anatomy and Physiology of the Small and Large Intestines
31. Maldigestion and Malabsorption
32. Protracted Diarrhea
33. Protein-Losing Enteropathy
34. Celiac Disease
35. Short Bowel Syndrome
36. Small Bowel Transplant
37. Allergic and Eosinophilic Gastrointestinal Disease
38. Infectious Diarhea
39. Enteric Parasites
40. Gastrointestinal Manifestations of Primary Immunodeficiency - Gastrointestinal Complications of Secondary Immunodeficiency Syndromes
41. Pediatric Polyposis Syndromes
42. Crohn's Disease
43. Ulcerative Colitis in Children and Adolescents
44. Chronic Intestinal Pseudo-Obstruction45. Neonatal Necrotizing Enterocolitis
46. Disorders of the Anorectum: Fissures, Fistulas, Prolapse, Hemorrhoids, Tags
47. Neoplasms of the Gastrointestinal Tract
48. Neoplasms of the Liver
49. Other Diseases of the Small Intestine and Colon
50. Appendicitis

VI Pediatric Surgical Disorders
51. Intussusception in Infants and Children
52. Inguinal Hernias and Hydroceles
53. Meckel's Diverticulum and Other Omphalomesenteric Duct Remnants
54. Hirschsprung's Disease
55. Imperforate Anus
56. Abnormal Rotation and Fixation of the Intestine
57. Small and Large Bowel Stenosis and Atresias
58. Newborn Abdominal Wall Defects
59. Stomas of the Small and Large Intestine

VII Gastrointestinal Procedures
60. Esophagogastr Oduodenoscopy, and Related Techniques
61. Colonoscopy, Polypectomy, and Related Techniques
62. Endoscopic Retrograde Cholangiopancreatography
63. Capsule Endoscopy and Small Bowel Enteroscopy
64. Gastrointestinal Motility Procedures
65. Gastrointestinal Pathology
66. Liver Pathology

VIII The Liver and Bile Ducts
67. Developmental Anatomy and Physiology of the Liver and Bile Ducts
68. Neonatal hepatitis
69. Biliary Atresia and Neonatal Disorders of the Bile Ducts
70. Pediatric Cholestatic Liver Disease with Genetic Etiology
71. Mitochondrial Hepatopathies: Disorders of Fatty Acid Oxidation and the Respiratory Chain
72. Abronmalities of Hepatic Protein Metabolism
73. Abnormalities of Carbohydrate Metabolism and the Liver
74. Nonalcoholic Fatty Liver Disease
75. Acute and Chronic Hepatitis
76. Portal Hypertension
77. Liver Failure
78. Liver Transplantation in Children
79. Diseases of the Gallbladder

IX The Pancreas
80. Pancreatic Development
81. Cystic Fibrosis and Congenital Anomalies of the Exocrine Pancreas
82. Pancreatitis
83. Total Pancreatectomy with Autoislet Transplantation, and Pancreatic Allotransplantation
84. Secretory Neoplasms of the Pancreas
85. Infant and Toddler Nutrition

X Nutrition
86. Nutritional Assessment
87. Tubes for Enteric Access
88. Parenteral Nutrition
89. Enteral Nutrition
90. Management of Diarrhea
91. Effects of Digestive Diseases on Bone Metabolism
92. Nutrition and Feeding for Children with Developmental Disabilities
93. Fecal Transplant
94. Questions

Now with full-color illustrations throughout, dozens of new review questions, and state-of-the-art coverage of this fast-changing area, Pediatric Gastrointestinal and Liver Disease, 6th Edition, remains the leading text in the field. You’ll find definitive guidance on diagnosis and treatment from experienced editors Drs. Robert Wyllie, Jeffrey S. Hyams, and Marsha Kay, as well as globally renowned contributors who share their knowledge and expertise on complex issues.

• Online videos of endoscopy procedures
• Knowledge updates- new research and treatments
• 4-color images online
• 2-color figures throughout the text
• Board review questions online
• 4-color-plate section
• 1 vol - Comprehensive without being too long
• International approach

• Robert Wyllie, MD, Chief of Medical Operations, Associate Chief of Staff, Cleveland Clinic, Professor of Pediatrics, Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio.
• Jeffrey S. Hyams, MD, Head, Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children's Medical Center, Hartford, Connecticut; Professor of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut.
• Marsha Kay, MD, Chair, Department of Pediatric Gastroenterology and Nutrition, Director, Pediatric Endoscopy, Cleveland Clinic Children’s Hospital, Cleveland, Ohio