PEDIATRIC LIVER TRANSPLANTATION. A CLINICAL GUIDE

1. Evolution of transplantation medicine
BRIEF HISTORY OF PLT
HEALTH SYSTEM BACKGROUND REQUIREMENTS FOR PLT
2. Before transplantation
Brain death criteria
Non-heart beating donors
Donor procurement
Managing a scarce resource: Differences in donor allocation across the world
INDICATIONS AND CONTRAINDICATIONS (and their evolution) - General aspects
(List of diagnoses)
PREPARATION FOR PLT
Medical (immunisations/cardiac/renal/neurological aspects)
Surgical and Radiological aspects
Psychological/Social aspects
3. Paediatric liver transplantation
ANAESTHETIC ASPECTS (Risk assessment)
SURGICAL ASPECTS (Choice of donor for PLT, Prevention of thrombosis/anticoagulation)
SURGICAL TECHNIQUES
Split graft
Living-related
Auxiliary
Domino
Techniques and present role of hepatocyte transplantation
STRATEGIES IN IMMUNE SUPPRESSION (Immune ablation, renal-sparing, steroid-sparing)
4. Management after Transplantation
INTENSIVE CARE ASPECTS
ANTI-INFECTION STRATEGIES
Viral
Bacterial
Fungal
EARLY COMPLICATIONS
SURGICAL (biliary, vascular, etc.)
MEDICAL
ROLE OF HISTOLOGY AFTER PLT
ROLE OF RADIOLOGY AND INTERVENTIONAL RADIOLOGY AFTER PLT
LATE COMPLICATIONS
SURGICAL (graft re-modelling, secondary portal hypertension/shunts)
MEDICAL (recurrent disease post-PLT, de novo AIH, post-transplant lymphoproliferative disease, nephrotoxicity)
PSYCHOSOCIAL ASPECTS AFTER PLT
(social reintegration, medication adherence, family planning, education)
PROSPECTS FOR IMMUNE TOLERANCE (possibilities for safe withdrawal of immunosuppression)
TRANSITION TO ADULT SERVICES (smooth handover of care to a different system)
FUTURE REQUIREMENTS

Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications.

Features:
• The first book completely dedicated to the practice of pediatric liver transplantation
• Brief chapters organized by topic will include: definition of the topic, pathophysiology, conventional management, controversies, and a bulleted summary
• Edited by leaders in the field with worldwide contributors representing different specialties associated with pediatric liver transplantation