PEDIATRIC THROMBOTIC DISORDERS

This comprehensive and authoritative text summarizes current evidence and provides experienced perspectives on the etiology, diagnosis, and management of pediatric thrombotic disorders, including arterial ischemic stroke and cerebral sinovenous thrombosis. Authored by leaders in the field, individual chapters are devoted to specific anatomic sites and types of thrombosis. State-of-the-art, pediatric-focused chapters aid in diagnostic evaluation and therapeutic decision making, in settings ranging from the most routine to the most complex and challenging patient scenarios. Topics include: extremity and caval deep venous thrombosis; pulmonary embolism; cancer-associated thromboembolism; infection-associated thromboembolism; arterial ischemic stroke; cerebral sinovenous thrombosis; gastrointestinal and visceral thrombosis; developmental hemostasis; thrombophilias; heparin-induced thrombocytopenia/thrombosis syndrome; venous thromboembolism prevention; thrombolysis; and novel anticoagulants, among others. This text is a 'must-have' for practitioners in pediatric hematology, oncology, hematopoietic stem cell transplantation, neurology, hospital medicine, and intensive care.
- Includes practical approaches to diagnosis and management across a large breadth of presentations of pediatric thrombotic disorders
- Contains chapters devoted to a broad array of thromboembolism types and sites, as well as novel and emerging therapies, facilitating an unparalleled depth of up-to-date comprehension of pediatric thromboembolism
- Identifies key unanswered questions in pediatric thrombotic disorders, stimulating future investigation

Authors
Neil A. Goldenberg, The Johns Hopkins University School of Medicine
Neil A. Goldenberg is Associate Professor of Pediatrics, Johns Hopkins University School of Medicine, and Chief Research Officer and Director, Thrombosis Program, All Children's Hospital, Johns Hopkins Medicine, St Petersburg, FL, USA.
Marilyn J. Manco-Johnson, Hemophilia and Thrombosis Center, University of Colorado, Denver
Marilyn J. Manco-Johnson is Director, Hemophilia and Thrombosis Center, and Professor of Pediatrics, University of Colorado, Aurora, CO, USA.

Contents
Preface
Part I. Epidemiology, Etiology, Diagnosis, Treatment, Outcomes:
1. Extremity and caval deep venous thrombosis Madhvi Rajpurkar and Shoshana Revel-Vilk
2. Pulmonary embolism Suzan Williams and Michael Wang
3. Cerebral sinovenous thrombosis in children and neonates Mahendranath Moharir and Gili Kenet
4. Gastrointestinal and visceral thromboembolism Courtney A. Lyle and Christoph Male
5. Renal and adrenal vein thrombosis Robert Francis Sidonio, Jr and Leonardo R. Brandao
6. Cancer and thrombosis Uma Athale
7. Epidemiology, etiology and pathophysiology of infection-associated venous thromboembolism in children Anjali A. Sharathkumar, Neil A. Goldenberg and Anthony K. C. Chan
Part II. Special Considerations in Pediatric Patients:
8. Developmental hemostasis I Paul Monagle
9. Developmental hemostasis II Marilyn J. Manco-Johnson
10. Pediatric thrombophilia evaluation: considerations for primary and secondary venous thromboembolism prevention Ulrike Nowak-Göttl, Gili Kenet and Neil A. Goldenberg
11. Role of global assays in thrombosis and thrombophilia Meera Chitlur and Mindy Simpson
12. Heparin-induced thrombocytopenia and thrombosis syndrome in children Courtney D. Thornburg
13. Severe thrombophilias Cameron C. Trenor, III and Marilyn J. Manco-Johnson
14. Thrombolysis Donald L. Yee, Catherine M. Amlie-Lefond and Peter H. Lin
15. New anticoagulants in children: a review of recent studies and a look to the future G. Young and Neil A. Goldenberg
16. Prevention of VTE in children Brian R. Branchford and Leslie Raffini
17. Arterial ischemic stroke in children Timothy J. Bernard and Ulrike Nowak-Göttl
Index.