PEREZ AND BRADY'S PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY

• Section I Overview and Basic Science of Radiation Oncology
1. The Discipline of Radiation Oncology
Edward C. Halperin, David E. Wazer, and Carlos A. Perez
Part A: Cancer Biology
2. Biologic Basis of Radiation Therapy
William H. McBride and H. Rodney Withers
3. Molecular Cancer and Radiation Biology
Michael Baumann, Nils Cordes, Mechthild Krause, and Daniel Zips
4. Molecular Pathophysiology of Tumors
Rakesh K. Jain and Dan G. Duda
5. Smart Radiotherapy
C. Norman Coleman, Eric J. Bernhard, Jacek Capala, Bhadrasain Vikram, and James A. Deye
Part B: Medical Radiation Physics
6. Principles of Radiologic Physics and Dosimetry
James A. Purdy
7. Photon External-Beam Dosimetry and Treatment Planning
James A. Purdy and Eric E. Klein
8. Electron-Beam Therapy Dosimetry, Treatment Planning, and Techniques
Eric E. Klein and Rojano Kashani
9. Conformal Radiation Therapy Physics, Treatment Planning, and Clinical Aspects
James A. Purdy
10. Intensity-Modulated Radiation Treatment Techniques and Clinical Applications
K.S. Clifford Chao, Radhe Mohan, Timothy D. Marinetti, and Lei Dong
11. Image-Guided Radiation Therapy
Loren K. Mell, William Y. Song, Todd Pawlicki, and Arno J. Mundt

• Section II Techniques, Modalities, and Modifiers in Radiation Oncology
12. Altered Fractionation Schedules
Anesa Ahamad
13. Late Effects and QUANTEC
John P. Kirkpatrick, Michael T. Milano, Louis S. Constine, Zeljko Vujaskovic, and Lawrence B. Marks
14. Methodology of Clinical Trials
Yaacov Richard Lawrence, James J. Dignam, and Maria Werner-Wasik
15. Total-Body and Hemibody Irradiation
Kenneth B. Roberts, Zhe Chen, and Stuart Seropian
16. Stereotactic Radiosurgery and Radiotherapy
John C. Flickinger and Ajay Niranjan
17. Stereotactic Irradiation of Tumors Outside the Central Nervous System
Brian D. Kavanagh, Jeffrey D. Bradley, and Robert D. Timmerman
18. Intraoperative Radiotherapy
Timothy J. Kinsella
19. Proton Therapy
Nancy Price Mendenhall and Zuofeng Li
20. Carbon Ions
Pascal Pommier, Stephanie E. Combs, and Tadashi Kamada
21. Methods of Immobilization and Stabilization
Joshua Evans, Edwin Crandley, Bruce Libby, and Stanley Benedict
22. Physics and Biology of Brachytherapy
Jeffrey F. Williamson, X. Allen Li, and David J. Brenner
23. Clinical Applications of Brachytherapy: Low-Dose Rate and Pulsed-Dose Rate
Alexandra J. Stewart, Caroline L. Halloway, and Phillip M. Devlin
24. The Physics and Dosimetry of High–Dose-Rate Brachytherapy
Bruce Thomadsen and Rupak K. Das
25. Clinical Aspects and Applications of High–Dose-Rate Brachytherapy
Subir Nag and Granger R. Scruggs
26. Radioimmunotherapy and Unsealed Radionuclide Therapy
Tod W. Speer
27. Photodynamic Therapy
Harry Quon, Charles B. Simone, II, Keith A. Cengel, Jarod C. Finlay, Timothy C. Zhu, and Theresa M. Busch
28. Radiation Oncology in the Developing World
Timothy P. Hanna
29. Chemical Modifiers of Radiation Response
David S. Yoo and David M. Brizel
30. Oncologic Imaging/Oncologic Anatomy
Christopher R. Kelsey, Junzo P. Chino, Jared D. Christensen, and Lawrence B. Marks
31. Hyperthermia as a Treatment Modality
Mark W. Dewhirst, Paul Stauffer, Zeljko Vujaskovic,
Chelsea D. Landon, and Leonard R. Prosnitz
32. Basic Concepts of Chemotherapy and Irradiation Interaction 604
D. Nathan Kim, Michael Story, and Hak Choy

• Section III Clinical Radiation Oncology
Part A: Skin
33. Skin
William M. Mendenhall, Anthony A. Mancuso, Jessica M. Kirwan, John W. Werning, and Franklin P. Flowers
Part B: Aids-Related Malignancies
34. Neoplasms Associated with Acquired Immunodeficiency Syndrome
Bernadine R. Donahue and Jay S. Cooper
Part C: Central Nervous System
35. Primary Intracranial Neoplasms
Vinai Gondi, Michael A. Vogelbaum, Sean Grimm, and Minesh P. Mehta
36. Pituitary Gland Cancer
Theodore E. Yaeger
37. Spinal Canal
Jiayi Huang, Cliff Robinson, and Jeff M. Michalski
Part D: Head and Neck
38. Eye and Orbit
Nicholas J. Sanfilippo and Silvia C. Formenti
39. Ear
Tony J.C. Wang and K.S. Clifford Chao
40. Locally Advanced Squamous Carcinoma of the Head and Neck
David M. Brizel and David J. Adelstein
41. Nasopharynx
Benjamin H. Lok, Jeremy Setton, Felix Ho, Nadeem Riaz, Shyam S. Rao, and Nancy Y. Lee
42. Cancer of the Nasal Cavity and Paranasal Sinuses
Steven J. Frank, Anesa Ahamad, and K. Kian Ang
43. Salivary Gland Cancer
Chris H.J. Terhaard
44. Oral Cavity
Rafael R. Mañon, Jeffrey N. Myers, Heath D. Skinner, and Paul M. Harari
45. Oropharynx
Joseph K. Salama, Maura L. Gillison, and David M. Brizel
46. Hypopharynx
Timothy J. Kruser, Hiral K. Shah, Henry T. Hoffman, Nitin A. Pagedar, and Paul M. Harari
47. Laryngeal Cancer
William M. Mendenhall, Anthony A. Mancuso, Robert J. Amdur, and John W. Werning
48. Unusual Nonepithelial Tumors of the Head and Neck
Carlos A. Perez and Wade L. Thorstad
49. Neck Cancer Including Unknown Primary Tumor
William M. Mendenhall, Anthony A. Mancuso, Robert J. Amdur, and John W. Werning
50. Thyroid Cancer
Roi Dagan and Robert J. Amdur
Part E: Thorax
51. Lung Cancer
Ramesh Rengan, Indrin J. Chetty, Roy Decker, Corey J. Langer, William P. O’Meara, and Benjamin Movsas
52. Mediastinal and Tracheal Cancer
Daniel R. Gomez, C. David Fuller, Sravana Chennupati, and Charles R. Thomas, Jr.
53. Esophageal Cancer
Brian G. Czito, Albert S. DeNittis, Manisha Palta, and Christopher G. Willett
54. Tumors of the Heart, Pericardium, and Great Vessels
Lawrence J. Sheplan Olsen, Gregory M.M. Videtic, and Roger M. Macklis
Part F: Breast
55. Breast Cancer: Stage Tis
David E. Wazer and Douglas W. Arthur
56. Breast Cancer: Early Stage
Sharad Goyal, Thomas A. Buchholz, and Bruce G. Haffty
57. Breast Cancer: Locally Advanced and Recurrent Disease, Postmastectomy Radiation, Systemic Therapies
Thomas A. Buchholz, David E. Wazer, and Bruce G. Haffty
Part G: Gastrointestinal
58. Stomach Cancer
Brian G. Czito, Manisha Palta, and Christopher G. Willett
59. Pancreatic Cancer
Manisha Palta, Christopher G. Willett, and Brian G. Czito
60. Cancer of the Liver and Hepatobiliary Tract
Mirrorer M. Liu, Skye H. Cheng, and Andrew T. Huang
61. Cancer of the Colon and Rectum
Manisha Palta, Christopher G. Willett, and Brian G. Czito
62. Anal Cancer
Bernard J. Cummings and James D. Brierley
Part H: Urinary Tract
63. Cancer of the Kidney, Renal Pelvis, and Ureter
Hiram A. Gay and Jeff M. Michalski
64. Bladder Cancer
Nicholas James, Richard T. Bryan, Richard Viney, Prashant Patel, and Syed A. Hussain
Part I: Male Genitourinary
65. Low-Risk Prostate Cancer
Michael J. Zelefsky, Megan E. Daly, and Richard K. Valicenti
66. Intermediate- and High-Risk Prostate Cancer
Hans T. Chung and Mack Roach, III
67. Testicular Cancer
Gerard C. Morton
68. Cancer of the Penis and Male Urethra
David B. Mansur
Part J: Gynecologic
69. Uterine Cervix
Akila N. Viswanathan
70. Endometrial Cancer
Kaled M. Alektiar
71. Ovarian and Fallopian Tube Cancer
Larissa Lee, Ross Berkowitz, and Ursula Matulonis
72. Vaginal Cancer
Josephine Kang and Akila N. Viswanathan
73. Cancer of the Female Urethra
Tony Y. Eng
74. Carcinoma of the Vulva
Junzo P. Chino, Laura J. Havrilesky, and Gustavo S. Montana
Part K: Retroperitoneum and Adrenal Gland
75. Retroperitoneal Cancer
Jeffrey C. Buchsbaum, James G. Douglas, Barnali Dasgupta, and Brian D. Lawenda
76. Adrenal Cancer
Filip T. Troicki and John J. Coen
Part L: Lymphoma and Hematologic Tumors
77. Hodgkin Lymphoma
Richard T. Hoppe
78. Non-Hodgkin Lymphomas
Leonard R. Prosnitz, Manisha Palta, and Christopher R. Kelsey
79. Primary Cutaneous Lymphomas
James E. Hansen, Youn H. Kim, Richard T. Hoppe, and Lynn D. Wilson
80. Leukemia
Kenneth B. Roberts, Stuart Seropian, and Peter W. Marks
81. Plasma Cell Myeloma and Plasmacytoma
David C. Hodgson, Joseph Mikhael, and Richard W. Tsang
Part M: Bone and Soft Tissue
82. Osteosarcoma and Other Primary Tumors of Bone
Jaroslaw T. Hepel and Timothy J. Kinsella
83. Soft Tissue Sarcoma (Excluding Retroperitoneum)
Elizabeth H. Baldini
Part N: Pediatric
84. Central Nervous System Tumors in Children
Carolyn R. Freeman, Jean-Pierre Farmer, and Roger E. Taylor
85. Wilms Tumor
John A. Kalapurakal and Patrick R.M. Thomas
86. Neuroblastoma
David B. Mansur and Jeff M. Michalski
87. Rhabdomyosarcoma
John C. Breneman and Sarah S. Donaldson
88. Ewing Tumor
Robert B. Marcus, Jr.
89. Lymphomas in Children
Monika L. Metzger, Hiroto Inaba, Stephanie Terezakis, and Louis S. Constine
90. Unusual Tumors in Children
Christian Carrie and Abraham Kuten
Part O: Benign Diseases
91. Nonmalignant Diseases
Karen M. Winkfield, Jose G. Bazan, Iris C. Gibbs, Tony Y. Eng, and Charles R. Thomas
92. Endovascular Brachytherapy
Ray Lin and Prabhakar Tripuraneni

• Section IV Palliative and Supportive Care
93. Palliation of Brain and Spinal Cord Metastases
Elizabeth M. Nichols, Roy A. Patchell, William F. Regine, and Young Kwok
94. Palliation of Bone Metastases
William F. Hartsell and Santosh Yajnik
95. Palliation of Visceral Recurrences and Metastases and Treatment of Oligometastatic Disease
Ramji R. Rajendran, Siavash Jabbari, and William F. Hartsell
96. Pain Management
Gary Deng, Amitabh Gulati, and Barrie R. Cassileth
97. Supportive Care and Quality of Life
Gary Deng and Barrie R. Cassileth

• Section V Economics, Ethics, and Technology Assessment
98. Technology Assessment, Outcome Analysis Research, Comparative Effectiveness, and Evidence-Based Radiation Oncology
Carlos A. Perez, Edward C. Halperin, and Yolande Lievens
99. Ethics, Professional Values, and Legal Considerations in Radiation Oncology
Brian D. Kavanagh, Laurie J. Lyckholm, and Jeremy Sugarman
100. Economics of Radiation Oncology
Paul J. Schilling

Index

Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book’s comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with a completely revamped digital experience, powered by Inkling!

NEW to the Sixth Edition…
• Site-specific chapters include relevant background information on each tumor—including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more.
• Over 1,400 full-color illustrations highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
• Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy.
• Greater emphasis on palliative and supportive care reflects the role of radiation treatment in non-curative roles.
• New editors and contributors let you benefit from their decades of experience.
• Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more.


Authors
• Edward C. Halperin MD. Vice Dean of the School of Medicine, Associate Vice Chancellor for Health Affairs, R.J. Reynolds Professor of Medical Education, Professor, Department of Radiation Oncology, Professor, Department of Pediatrics, Duke University Medical Center, Durham, NC
• Luther W. Brady MD. Professor, Department of Radiation Oncology, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA
• Carlos A. Perez MD. Mallinckrodt Institute of Radiology, Washington University Medical Center, St. Louis, MO
• David E. Wazer MD. Department of Radiation Oncology, Tufts-New England Medical Center, Boston, MA