PHARMACEUTICAL BIOTECHNOLOGY. FUNDAMENTALS AND APPLICATIONS. 4TH EDITION

1. Molecular Biotechnology: From DNA Sequence to Therapeutic Protein
2. Biophysical and Biochemical Analysis of Recombinant Proteins
3. Production and Purification of Recombinant Proteins
4. Formulation of Biotech Products, Including Biopharmaceutical Considerations
5. Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics
6. Immunogenicity of Therapeutic Proteins
7. Monoclonal Antibodies: From Structure to Therapeutic Application
8. Genomics, Other “Omic” Technologies, Personalized Medicine, and Additional Biotechnology-Related Techniques
9. Dispensing Biotechnology Products: Handling, Professional Education, and Product Information
10. Economic Considerations in Medical Biotechnology
11. Regulatory Framework for Biosimilars
12. Insulin
13. Follicle-Stimulating Hormone
14. Human Growth Hormone
15. Recombinant Coagulation Factors and Thrombolytic Agents
16. Recombinant Human Deoxyribonuclease I
17. Monoclonal Antibodies in Cancer
18. Hematopoietic Growth Factors: Focus on Erythropoiesis-Stimulating Agents
19. Monoclonal Antibodies in Solid Organ Transplantation
20. Monoclonal Antibodies and Antibody-Based Biotherapeutics in Inflammatory Diseases
21. Interferons and Interleukins
22. Vaccines
23. Oligonucleotides
24. Gene Therapy
25. Stem Cell Technology

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

Features
• Explains the basic science and the applications of biotechnology-derived pharmaceuticals
• Serves as a complete one-stop source for undergraduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry
• Includes additional coverage on the newer approaches

Authors
• DAAN J.A. CROMMELIN is Professor at the Department of Pharmaceutics at Utrecht University. Until December 2011 he was scientific director of the Dutch Top Institute Pharma in Leiden. He is adjunct professor at the Department of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah. Dr. Crommelin is co-founder of OctoPlus, a Leiden based company specialized in the development of pharmaceutical product formulations and advanced drug delivery systems. He published over 335 articles and has held leadership positions at the International Pharmaceutical Federation (FIP) and the European Federation for Pharmaceutical Sciences (EUFEPS).
• ROBERT D. SINDELAR is currently President, The Providence Health Care Research Institute, Vice President Research and Academic, Providence Health Care (part of the British Columbia public health care system), Professor Faculty of Pharmaceutical Sciences and Associate Dean Research Faculty of Medicine The University of British Columbia (UBC). He served for 11 years as Dean and Professor, The UBC Faculty of Pharmaceutical Sciences following 19 years at the University of Mississippi where he held the positions of Professor and Chair of Medicinal Chemistry, School of Pharmacy and served as Interim Dean. Dr. Sindelar’s expertise lies in medicinal chemistry, computer-aided drug discovery and design, pharmaceutical biotechnology, and creating opportunities to integrate innovation into the health care system. His research work resulted in significant extramural funding and 70 refereed journal articles, six U.S. patents, and over 100 scientific and professional presentations. He has been active in promoting the profession of pharmacy and the biotechnology community. Dean Sindelar has helped build a unified vision for the future of pharmacy and pharmaceutical sciences education in BC and beyond and has been inducted as a fellow in the Canadian Academy of Health Sciences.
• BERND MEIBOHM is Professor of Pharmaceutical Sciences and Associate Dean for Research and Graduate Programs at the University of Tennessee College of Pharmacy in Memphis. His area of expertise lies in clinical pharmacology and pharmacokinetic/pharmacodynamics correlations. Dr. Meibohm obtained his doctoral degree in Pharmaceutics from the Technical University Carolo-Wilhelmina, Braunschweig, Germany and received postdoctoral training at the University of Florida, Gainesville. Dr. Meibohm is a fellow of the American Association of Pharmaceutical Scientists and the American College of Clinical Pharmacology, and has published three textbooks, more than 90 peer-reviewed research articles and book chapters, 130 abstracts, and over 100 invited scientific presentations to national and international audiences.