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Part I. Introductory Part.
1. Evolving of concepts in fat grafting and Regenerative Surgery.
2. The Era of regenerative surgery.
3. Regenerative Surgery: Definitions and Background.
4. Current status on regenerative surgery.
5. Fluid balance, electrolytes, and anesthetic options in regenerative surgery and fat grafting.
6. Adipose Tissue Transplantation: Autologous versus cryopreserved (Frozen) versus heterologous. Present and future of fat transfer.
7. Comparison between fat and fillers.

Part II. Stem Cells and Clinical Path.
8. Features and biological properties of different adipose tissue based products. Milli-, Micro-, Emulsified (Nano-) fat, SVF and AD-multipotent mesenchymal stem cells.
9. Regenerative technologies and Adipose derived stem cells (ADSCs): regulatory, ethical and technical updates.
10. Stem Cell Research, Concepts, and Emerging Technologies.
11. Stem cells and their clinical applications.
12. Fat grafting, tissue banking and adipose stem cell therapies – European regulatory status in 2021.

Part III. Operative Techniques for Fat Grafting.
13. Aesthetic Lipofilling: Trends, Patient needs and Assessment.
14. New perspective in Regenerative Surgery: The Acellular Adipose Matrix.
15. New strategies in Regenerative Medicine: The Bio-Active Composite Grafts.
16. Injectable Tissue Replacement and Regeneration- A New Standardized Fat Grafting Technique.
17. Novel strategies to improve graft survival and retention.
18. Impact of age, gender, body mass index, harvesting site, suction pressure, smoking, Diabetes, Systemic Lupus and other diseases on the regenerative properties of the grafted adipose tissue.
19. Fat Processing Methods.
20. Classification of Safe Autologous Fat Grafting: Quantity and Location Site.
21. Complications in Regenerative and Fat Transfer Surgery: Pathophysiology and Management with Technical Tips to Reduce Risk.
22. Fat grafting and Fat embolism. How to prevent, diagnose and treat.
23. Potentials and Limitations of the role of platelet rich plasma (PRP) in lipofilling. An evidence based approach.
24. The Role of Nurses in Fat Grafting Procedures: Planning, Preparation, and Implementation.

Part IV. Regenerative Surgery: Reconstructive Areas of Application.
25. Fat grafting as plastic surgeons' best friend: solving complex reconstructions problems with simple regenerative solutions.
26. Treatment of radiation-induced rectovaginal fistula: Safety and efficacy of fat grafting and stromal-vascular fraction injections.
27. Treatment of fibrotic radiotherapy damages in head & neck with fat grafting.
28. Vampire scar: outpatient quality improvement of scar regeneration with a composite approach with needling and PRP.
29. Post-Burn And Keloid Scar Treatment With Adipose Derived Stems Cells (ADSC).
30. Treatment of chronic wounds with fat grafting and adipose-derived stromal-vascular fraction.
31. Fat grafting as an Ancillary treatment for burns and other complex wounds and their sequellae.
32. Treatment of scleroderma with Fat grafting, PRP and Adipose stem cells.
33. Scar modulations and maturation in post-burn scar contractures and skin grafts using autologous fat injections grafts.
34. Complex Regional Pain Syndrome and Steroid Atrophy Scar Retraction treatment with Adipose Grafting.
35. Acute Burns management. The current role of regenerative surgery and its challenges.
36. Regenerative surgery choices in Burns sequelae management.
37. Fat and stromal cells for acute burn treatment.
38. Physical therapies to improve fat grafting and regenerative surgery results in wound healing.
39. Combined fat, PRP and Laser for skin and soft tissues regeneration. Clinical applications.
40. Regenerative surgery and acellular dermal matrix as reconstructive surgical options in plastic surgery. Theoretical and practical basis.
41. The role of adipose tissue graft on nerve regeneration from the perspective of the adipose derived stem cell.
42. Cellular Optimized Nanofat for Microneedling and as a Unique Nanofat Biocrème.

Part V. Regenerative Surgery: Aesthetic Areas of Application, Hair.
43. Hair re-grow with Micrografts enriched with Human Follicle Mesenchymal Stem Cells and Platelet Rich Plasma.
44. The Efficacy of Platelet-Rich Plasma for Hair Loss: A Proven Therapy.

Part VI. Regenerative Surgery: Aesthetic Areas of Application, Skin.
45. The Process of Aging, State-of-the-art: Evidence Behind Regenerative Surgery.
46. Wrinkles: Etiology, Causes, treatment, and prevention.
47. Skin and Structural Aging in Patients of African Ethnicity. Features, management and the role of regenerative surgery.
48. The use of the fat grafting to improve skin quality.

Part VII. Regenerative Surgery Aesthetic and Reconstructive Areas of Application, Face.
49. Surgical anatomy in regenerative surgery of face, scalp and neck.
50. Facial Fat Grafting during Facelift Surgery.
51. Properly Diluted Fat (P.D.F.): A safer approach to periocular fat grafting.
52. Improved Facial Rejuvenation and Scar Regeneration by the Autologous Stemcell-Enriched Lipoconcentrate.
53. Aesthetic Chin augmentation with fat: Is there still a need for chin implants?.
54. Micro fat graft in facial rejuvenation.
55. Transgender Facial Aesthetics and Regenerative Techniques.
56. Posttraumatic contour deformities reconstruction and scars treatment with Microstructural and nano fat grafting in the face.
57. Nanofat grafting in facial rejuvenation: an innovative technique.
58. Parry- Romberg Syndrome treatment with Microstructural fat grafting of the face.
60. The regenerative approach for the Management of severe dysphonia.
62. Degenerative retinopathy treatment with ADSC. Our experience.

Part VIII. Breast Augmentation and mastopexi with Fat.
63. Aesthetic Breast Augmentation Using Autologous Fat Grafting: Indications, Patient Assessment, and Comparison Between Different Processing Methods in 204 Cases.
64. New Trends in Breast Augmentation With Fat Grafting: Implant Conversion With Fat and Hybrid Implant-Fat Breast Augmentation.
65. Implant Conversion with fat grafting.
66. Composite Breast Augmentation with Implants and Fat Grafting.
67. Autologous Fat Grafting for breast augmentation in Asian women.
68. Improving Breast Footprint and Shape using Anchor Threads in Fat Grafting Breast Augmentation.
69. Breast augmentation with fat and threads using Power-Assisted Liposuction, Loops and Lipofilling (PALLL) technique.
70. Stromal Enriched Lipograft for Breast Augmentation.
71. Treatment of tuberous breast with fat.
72. Mastopexy with autoaugmentation and fat grafting.
73. Correction of severe congenital breast asymmetry in Poland syndrome and other breast asymmetries with autologous microstructural fat transfer and the combination of other techniques.
74. Inverted nipple correction with Central Tunnel Technique and fat grafting.

Part IX. Breast Reconstruction with Fat.
76. The Prepectoral, Hybrid Breast Reconstruction: the Synergy of Lipofilling and Breast Implants.
77. Breast reconstruction with inferior flap and fat transfer as curative treatment for BIA-ALCL.
78. Breast reconstruction with fat and threads using Power-Assisted Liposuction, Loops and Lipofilling (PALLL) technique.
79. Enhancing Flap breast reconstruction with percutaneous purse-string suture and fat grafting.
80. Lipomodeling for breast conservative treatment sequelae (precautions, indications, results).
81. Lipomodelling as perfect complement to autologous latissimus dorsi flap breast reconstruction.
83. Revision surgery with fat grafting after implant and flap breast reconstruction.
84. Stem cell enriched fat injection in aesthetic, reconstructive breast surgery.
85. Safety of autologous fat transplantation in oncological postmastectomy breast reconstruction. A prospective study.
86. Oncologic safety of fat graft to the breast.

Part X. Gluteal Augmentation with Fat, Brazilian Butt Lift (BBL) and Related Body Contouring.
87. Gluteal Augmentation with Fat: Patient Assessment, Operative Technique and Safety Guidelines.
88. Artnatomy for advanced body contouring and Aesthetic balance between breast and body.
89. Gluteal augmentation with fat and threads using Power-Assisted Liposuction, Loops and Lipofilling (PALLL) technique.
90. Expansion Vibration Lipofilling (EVL) technique in Gluteal augmentation and waist feminization.
91. Gluteal augmentation: Avoidance of intramuscular injection using precise superficial fat graft technique.
92. Gluteal Augmentation Assisted by Stromal Enriched Lipograft.
93. Circumferential lipoabdominoplasty combined with Fat grafting the hips and buttocks.
94. MWL and post barriatric surgery patients: the role of fat grafting and regenerative surgery.
95. High Definition Abdominal Sculpting with Fat Grafting Highlights.
96. Safety for advanced body contouring: The darkest Hour.

Part XI. Genital Rejuvenation.
97. Surgical Anatomy of genital area to achieve Safety in fat grafting.
98. Quality of Life and Rejuvenation Techniques in Female Intimate Cosmetic Genital Surgery.
99. Fat grafting and Adipose Stem Cells to treat vulvar scarring and fibrosis post Female Genital Mutilation (FGM).
100. The treatment of genital Vulvar and Penile Lichen Sclerosus with Autologous Fat Grafting.
101. Fat Grafting to Treat Vulvo-vaginal Stenosis.
102. Vulvovaginal rejuvenation by fat and stromal cells.
103. Fat grafting as a regenerative measure for Vulvar atrophy and Vaginal laxity.
104. Fat graft for the treatment of vulvar and vaginal laxity.
105. Microfat and nanofat grafting in genital rejuvenation.
106. Male Genital Regenerative surgery.
107. Penile enlargement by fat grafting.

Part XII. Upper Extremity.
108. Microfat grafting in Dupuytren’s contracture: from hypodermis reconstruction and scar optimization to recurrence prevention.
109. Management of Dupuytren’s disease. The role of regenerative surgery. Overview.
110. Hands function and aesthetic with regenerative surgery.
111. Hand Rejuvenation by minimally invasive injection of Stromal Enriched Lipograft.
112. Emulsified fat grating to the atrophic post traumatic digital pulp: a promising reconstruction procedure.

Part XIII. Lower Extremity.
113. Fat grafting in the surgical treatment of pressure sores and as a preventive measure against recurrences.
114. Fat grafting for pedal fat pad atrophy.
115. Leg Augmentation With Autologous Fat Tissue.
116. Composite calf augmentation combing fat and implants.
117. Osteoarthritis of the knee: Comparison between intra-articular injection of adipose-derived stromal vascular fraction and nanofat.

Readers will discover the relatively new and rapidly growing field of regenerative surgery and fat grafting, valuable for numerous plastic surgery, reconstructive, and aesthetic/cosmetic essentials.
Though many books have covered specific areas or topics in regenerative surgery, the market lacks a work that tackles the full spectrum of regenerative surgery and its clinical application. This book responds to that need and presents chapters written by the best: world-renowned surgeons in their field.
After an introduction that reflects basic research, most of the book focuses on clinical experience as it relates to applied techniques of processing fat and on the different uses from head to toe. Readers will learn about the history of regenerative surgery, important definitions and background information, and the evidence supporting the use of regenerative surgery. Practitioners will also find valuable guidance regarding the application of stem cells, evaluation of patient needs, and operative techniques for fat transfer. Subsequent chapters address topics such as graft types, the skin, wound healing, scar treatment, osteoarthritis, burns, scleroderma, hair rejuvenation, facial enhancement combined with facelift, chin augmentation with fat, and breast argumentation or reconstruction with fat. Particular attention is paid to gluteal augmentation with fat, body contouring, genital male and female rejuvenation, and upper and lower extremity regenerative surgery. Surgical anatomy and complications treatment and prevention were emphasized when applied. This resulted is two volumes that encompass 125 chapters, with multiple figures, and video clips, written by 242 authors (including 72 female colleagues) from five continents.
Highly informative and carefully structured, this book provides invaluable insight for beginners and experienced plastic surgeons alike, while benefitting advanced surgeons, specialists, and undergraduate and graduate students.

• Comprehensively addresses surgical methods for all parts of the body
• Focuses on clinical techniques and practical application
• Shares the knowledge and expertise of the most experienced surgeons in the world in their field

Amin Kalaaji, MD, PhD, is the clinic chief and consultant plastic surgeon at Oslo Plastic Surgery Clinic in Oslo, Norway, a position he has held for the past 20 years. Dr. Kalaaji was also the president of the Norwegian Society of Aesthetic Plastic Surgery (NSAPS) from 2018 to 2020.

For 20 years, Dr. Kalaaji’s focus has been on aesthetic plastic surgery, including the use of fat grafting for various indications on the body—which is the subject of this text, Plastic and Aesthetic Regenerative Surgery and Fat Grafting: Clinical Application and Operative Techniques.

Dr. Kalaaji earned his medical degree from Aleppo, Syria, and completed his surgical training in Paris, France and Gothenburg, Sweden, where he also completed his PhD in bone grafting of the cleft lip and palate. For 10 years, Dr. Kalaaji was a consultant plastic surgeon/vice chief and chief at the plastic surgery department at Telemark Central Hospital and Oslo University Hospital in Norway.
Dr. Kalaaji has published many peer-reviewed scientific papers and has given more than 300 lectures, courses, and conference presentations in plastic and aesthetic surgery worldwide—for organizations such as the American Society for Aesthetic Plastic Surgery (ASAPS), the International Society for Aesthetic Plastic Surgery (ISAPS), the International Society of Plastic Regenerative Surgeons (ISPRES), and the International Master Course on Aging Science (IMCAS) in addition to speaking at many national and international meetings worldwide. He currently serves on the editorial boards for the Aesthetic Surgery Journal, the Journal of Plastic Surgery and Hand Surgery, and the Acta Chirurgiae Plasticae.

Dr. Kalaaji is also an active member and a board member of the Norwegian Society of Aesthetic Plastic Surgeons, and a former board member of the Norwegian Society of Plastic Surgeons. He is also an active member of the Swedish Society of Plastic Surgeons; the Nordic Society of Plastic Surgeons; and ASAPS, including its international and education/program committees, ISAPS and ISPRES.
In 2015, 2017, and 2019, Dr. Kalaaji served as chairman of the 1st, 2nd, and 3rd Norwegian American Aesthetic Meetings (NAAM 1, 2, 3) held in Oslo, Norway. In July 2017, he was elected as the national secretary for ISAPS in Norway for a term of 4 years, in addition to being on the membership committee from 2018 through 2020. In October 2018, after a unanimous vote, Dr. Kalaaji became a member of the executive board of directors of ISPRES. A month later, he was elected president of NSAPS—a position he held until the end of 2020. In 2020, Dr. Kalaaji also became the chairman of the membership committee of ISPRES and a member of the safety committee of ISAPS—a position he will hold until 2022.