PRACTICAL TRANSFUSION MEDICINE, 5TH EDITION

1 Introduction: Two Centuries of Progress in Transfusion Medicine 1
• Part I Basic Principles of Immunohaematology 11
2 Essential Immunology for Transfusion Medicine 11
3 Human Blood Group Systems 20
4 Human Leucocyte Antigens 29
5 Platelet and Neutrophil Antigens 43
6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58
• Part II Complications of Transfusions 69
7 Investigation of Acute Transfusion Reactions 69
8 Haemolytic Transfusion Reactions 81
9 Febrile and Allergic Transfusion Reactions 97
10 Lung Injury and Pulmonary Oedema After Transfusion 108
11 Purported Adverse Effects of ‘Old Blood’ 118
12 Transfusion ]Induced Immunomodulation 125
13 Transfusion ]Associated Graft ]Versus ]Host Disease and Microchimerism 136
14 Posttransfusion Purpura 147
15 Transfusion ]Transmitted Infections 153
16 Bacterial Contamination 168
17 Emerging Infections and Transfusion Safety 176
• Part III Practice in Blood Centres and Hospitals 18418 Regulatory Aspects of Blood Transfusion 184
19 The Role of Haemovigilance in Transfusion Safety 193
20 Donors and Blood Collection 203
21 Blood Donation Testing and the Safety of the Blood Supply 215
22 Production and Storage of Blood Components 222
23 Blood Transfusion in Hospitals 233
24 Blood Transfusion in a Global Context 254
• Part IV Clinical Transfusion Practice 264
25 Inherited and Acquired Coagulation Disorders 264
26 Massive Blood Loss 279
27 Blood Management in Acute Haemorrhage and Critical Care 287
28 Point ]of ]Care Testing in Transfusion Medicine 302
29 Haematological Disease 312
30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330
31 Heparin ]Induced Thrombocytopenia 341
32 Immunodeficiency and Immunoglobulin Therapy 357
33 Transfusing Neonates and Infants 371
• Part V Patient Blood Management 383
34 Development of a Patient Blood Management Programme 383
35 Perioperative Patient Blood Management 393
36 Restrictive Transfusion Practice and How to Implement It 405
37 Using Data to Support Patient Blood Management 416
• Part VI Cellular and Tissue Therapy and Organ Transplantation 429
38 Regulation and Accreditation in Cellular Therapy 429
39 Stem Cell Collection and Therapeutic Apheresis 442
40 Haemopoietic Stem Cell Processing and Storage 455
41 Haematopoietic Stem Cell Transplantation 466
42 Cord Blood Transplantation 477
43 Recent Advances in Clinical Cellular Immunotherapy 490
44 Tissue Banking 500
• Part VII Development of the Evidence Base for Transfusion 508
45 Observational and Interventional Trials in Transfusion Medicine 508
46 Getting the Most Out of the Evidence for Transfusion Medicine 520
47 A Primer on Biostatistics 533
48 A Primer on Health Economics 549
49 Scanning the Future of Transfusion Medicine 560

The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including new co-editor Mark H. Yazer MD.

• A succinct and user-friendly resource of transfusion medicine for clinicians, scientists and trainees with key points, charts and algorithms
• Discusses practice in blood centres and hospitals including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context
• Coverage of cellular and tissue therapies and organ transplantation including stem cell collection and haematopoietic stem cell processing and storage
• Review of the development of the evidence-base for transfusion medicine
• Content on the clinical practice for transfusion and alternatives to transfusion

Author Information
• MICHAEL F. MURPHY, Professor of Blood Transfusion Medicine, University of Oxford, UK
• DAVID J. ROBERTS, Professor of Haematology, University of Oxford, UK
• MARK H. YAZER, Professor of Pathology, University of Pittsburgh, USA; Adjunct Professor of Clinical Immunology, University of Southern Denmark, Denmark