RADIOGUIDED SURGERY. CURRENT APPLICATIONS AND INNOVATION DIRECTIONS IN CLINICAL PRACTICE

CONTENTS
• Part 1 Introduction.
- The History of Radioguided Surgery: Early Historical Milestones and the Development of Later Innovative Clinical Applications.
• Part 2 Detailed Methodology
• Part3 Physics of Radioguided Surgery
.- The use of intraoperative small and large field of view gamma cameras for radioguided surgery.
- Surgical Navigation.
- Tracers applied in radioguided surgery.
- Radiation Safety and Dosimetry.
• Part 3 Clinical Application: Breast.
- Radioguided sentinel lymph node mapping and biopsy in breast cancer.
- Radioguided Surgery for Non-Palpable Breast Lesions: I-125 Radioactive Seed Localization.
- Radioguided Surgery for Non-Palpable Breast Lesions: Technetium-99m Radioguided Occult Lesion Localization (ROLL).
• Part 4 Clinical Application: Skin.
- Radioguided sentinel lymph node mapping and biopsy in cutaneous melanoma.
• Part 5 Clinical Application: Head and Neck.
- Sentinel lymph node mapping and biopsy in oral cancer.
• Part 6 Clinical Application: Thyroid and Parathyroid.
- Radioguided sentinel lymph node mapping and biopsy in thyroid cancer.
- Radioguided Parathyroid Surgery.
- Radioguided surgery of thyroid carcinoma recurrences.
• Part 7 Clinical Application: Urogenital Tract.
- Radioguided sentinel lymph node biopsy and lymphatic mapping in urogenital malignancies.
- Radioguided sentinel lymph node mapping and biopsy in Gynaecological malignancie.
• Part 8 Clinical Application: Gastrointestinal Tract.
- Radioguided sentinel lymph node mapping and biopsy in oesophago-gastric.
- Radioguided sentinel lymph node mapping and biopsy in colorectal cancer.
- Radioguided surgery in gastro-entero-pancreatic neuroendocrine tumors.
• Part 9 Clinical Application: Thoracic.

• Details current clinical applications of radioguided surgery for a variety of malignancies
• Covers new technical developments and translation into clinical practice
• Written by nuclear medicine imaging specialists and surgeons

This book offers a comprehensive overview of the state of the art in the practice of radioguided surgery. The opening section is devoted to the basic physics principles for detection and imaging, radiation detection device technology, principles of surgical navigation, radionuclides and radiopharmaceuticals, and radiation safety. A series of chapters then address the clinical application of radioguided surgery for a variety of malignancies, including breast cancer, melanoma and other cutaneous malignancies, gynecologic malignancies, head and neck malignancies, thyroid cancer, urologic malignancies, colon cancer, gastroesophageal cancer, lung cancer, bone tumors, parathyroid adenomas, and neuroendocrine tumors. For each application, the recommended methodological approaches are discussed and the available cumulative clinical experiences of investigators from across the globe are reviewed. A conscious effort is made to highlight recent developments and innovative multidisciplinary approaches within each clinical area. Interesting issues and novel approaches are further explored through a collection of selected case reports at the end of the book. The contributing authors are all experts in their own fields, ensuring that the book will hold wide appeal for surgeons, surgical technologists, nuclear medicine physicians, nuclear medicine technologists, and various trainees.

Authors
• Ken Herrmann graduated from Charité Universitätsmedizin in Berlin, Germany in 2004. His medical studies included training at the Universite de Lausanne in Switzerland, Universidad Austral de Chile in Valdivia, and Memorial Sloan-Kettering Cancer Center in New York. Dr. Herrmann was trained in nuclear medicine at Technische Universität München under the guidance of Professor Markus Schwaiger. Dr. Herrmann received an executive MBA of the University of Zürich in Switzerland. Since 2011, he has been a faculty member of the Department of Molecular and Medical Pharmacology of the University of California, Los Angeles (UCLA). In addition, Dr. Herrmann serves as the Vice Chair of Nuclear Medicine at Universitätsklinikum Würzburg in Germany. Dr. Herrmann’s research focuses on radioguided surgery and its clinical applications, on radionuclide theranostics, and on PET-based response assessment to oncologic therapies.
• Stephen P. Povoski is a Surgical Oncologist at the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center of The Ohio State University Wexner Medical Center in Columbus, Ohio. Dr. Povoski received his B.S. Degree (summa cum laude) in Biological Sciences from the State University of New York at Buffalo in 1985, his M.D. Degree (summa cumlaude) from the State University of New York Health Science Center at Syracuse in 1989, completed his General Surgery Residency training at the University of Cincinnati Medical Center in 1996, and completed his Surgical Oncology Fellowship at Memorial Sloan-Kettering Cancer Center in 1998. Dr. Povoski’s clinical practice is focused on the diagnosis and treatment of breast cancer, and he has significant clinical expertise in radioguided sentinel lymph node mapping and biopsy technology and FDG-directed surgical interventions. Dr. Povoski’s research interests are primarily focused on the development of innovative strategies for perioperative and intraoperative tumor detection and tumor imaging (using both radiation-emitting agents and non-radiation-emitting agents), as well as the development of tumor-directed surgical and non-surgical therapeutic interventions. Dr. Povoski serves on the Editorial Board of multiple journals, is the Section Editor for the Surgical Oncology, Cancer Imaging, and Interventional Therapeutics section of the Springer Science+Business Media/BioMed Central journal, BMC Cancer, and was named the 2015 Section Editor of the Year for BioMed Central.