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1. Why Nuclear Imaging and Radiotherapy?
2. A Short History of Nuclear Medicine
3. The Basics of Nuclear Chemistry and Radiochemistry: An Introduction to Nuclear Transformations and Radioactive Emissions
4. Methods for the Production of Radionuclides for Medicine
5. An Overview of Targeted Radiotherapy
6. An Overview of Nuclear Imaging
7. Small Molecules as Radiopharmaceutical Vectors
8. Peptides as Radiopharmaceutical Vectors
9. Immunoglobulins as Radiopharmaceutical Vectors
10. Nanoparticles as Radiopharmaceutical Vectors
11. The Radiopharmaceutical Chemistry of Carbon-11: Basic Principles
12. The Radiopharmaceutical Chemistry of Carbon-11: Tracers and Applications
13. The Radiopharmaceutical Chemistry of Nitrogen-13 and Oxygen-15
14. The Radiopharmaceutical Chemistry of the Radionuclides of Gallium and Indium
15. The Radiopharmaceutical Chemistry of Fluorine-18: Nucleophilic Fluorinations
16. The Radiopharmaceutical Chemistry of Fluorine-18: Electrophilic Fluorinations
17. The Radiopharmaceutical Chemistry of Fluorine-18: Next-Generation Fluorinations
18. The Radiopharmaceutical Chemistry of Technetium-99m
19. The Radiopharmaceutical Chemistry of the Radioisotopes of Copper
20. The Radiopharmaceutical Chemistry of the Radioisotopes of Lutetium and Yttrium
21. The Radiopharmaceutical Chemistry of Zirconium-89
22. The Radiopharmaceutical Chemistry of the Radioisotopes of Iodine
23. The Radiopharmaceutical Chemistry of Alpha-Emitting Radionuclides
24. The Radiopharmaceutical Chemistry of Seldom-Used Radionuclides in Nuclear Medicine
25. Bioconjugation Methods for Radiopharmaceutical Chemistry
26. Click Chemistry in Radiopharmaceutical Chemistry
27. Equipment and Instrumentation for Radiopharmaceutical Chemistry
28. Kinetic Modeling of Radiotracers
29. An Introduction to Radiation Protection
30. An Introduction to Biostatistics
31. Choosing a Target for Nuclear Imaging or Targeted Radiotherapy
32. Target Identification, Lead Discovery, and Optimization
33. Preclinical Experimentation in Oncology
34. Preclinical Experimentation in Neurology
35. The Clinical Translation Process in Europe
36. The Clinical Translation Process in the United States
37. Setting Up a Successful Radiopharmaceutical Production Facility

This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic.
The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.”
This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

• Offers a comprehensive guide to radiopharmaceutical chemistry, a quickly growing field in nuclear medicine and radiology
• Each chapter is written by one of the most preeminent researchers in the field
• Combines basic science information with clinical implications to aid in clinical decision making