RECURRENT IMPLANTATION FAILURE. ETIOLOGIES AND CLINICAL MANAGEMENT

1. Signaling Between Embryo and Endometrium: Normal Implantation
2. Embryo and Endometrial Synchrony in Implantation Failure
3. Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?
4. Embryonic Factors Associated with Recurrent Implantation Failure
5. The Genetics of Pregnancy Failure
6. Immune Factors in Recurrent Implantation Failure
7. Stress and Implantation Failure
8. Hematologic Disease in Implantation Failure
9. Endocrine Causes of Implantation Failure
10. Anatomic Abnormalities and Recurrent Implantation Failure
11. Microbiome in Embryonic Implantation and Implantation Failure
12. Psychosocial Implications of Recurrent Implantation Failure

This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed.

Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists.

Features
• Discusses the wide range of causes and conditions resulting in recurrent implantation failure (RIF) and its current clinical management
• Examines genetic, immune and environmental factors as well as abnormalities of the anatomy, hematologic and endocrine systems leading to RIF
• Ideal for reproductive endocrinologists and infertility specialists working with these challenging patients

Authors
• Jason M. Franasiak, MD, TS (ABB), Assistant Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA
• Richard T. Scott, MD, HCLD/ALD (ABB), Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA