REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY, 2ND EDITION

• Section I. General
Chapter 1. Introduction
Chapter 2. Reproductive Anatomy and Physiology
Chapter 3. Pharmacokinetics in Pregnancy
Chapter 4. Physiologically Based Pharmacokinetic Models in Reproductive and Developmental Toxicology
Chapter 5. Drugs and Chemical Contaminants in Human Breast Milk
• Section II. Toxicity Testing Models and Safety Evaluation
Chapter 6. Reproductive and Developmental Safety Evaluation of New Pharmaceutical Compounds
Chapter 7. Juvenile Toxicology Testing
Chapter 8. Postmarket Surveillance and Regulatory Considerations in Reproductive and Developmental Toxicology: A Food and Drug Administration Perspective
Chapter 9. OECD Guidelines for In Vivo Testing of Reproductive Toxicity
Chapter 10. Guidelines for Reproductive and Developmental Toxicity Testing and Risk Assessment of Chemicals
Chapter 11. Validated and Nonvalidated Mechanism-Based Methods for Testing Developmental Toxicity
Chapter 12. Relevance of Animal Testing and Sensitivity of End Points in Reproductive and Developmental Toxicity
Chapter 13. Embryonic Toxic Lesions and Stem Cell Therapy
Chapter 14. In Vitro and Alternative Approaches to Developmental Neurotoxicity
Chapter 15. In Vitro Biomarkers of Developmental Neurotoxicity
Chapter 16. Using Zebrafish to Assess Developmental Neurotoxicity
Chapter 17. Caenorhabditis elegans as a Model to Assess Reproductive and Developmental Toxicity
Chapter 18. A Primate as an Animal Model for Reproductive and Developmental Toxicology Testing
• Section III. Nanoparticles and Radiation
Chapter 19. Developmental Toxicity of Engineered Nanomaterials
Chapter 20. Toxicity of Radiation: Biological Effects of Ionizing Radiation Exposure on Reproduction
• Section IV. Gases and Solvents
Chapter 21. Reproductive and Developmental Toxicity of Solvents and Gases
• Section V. Drugs of Abuse and Addiction, Smoking and Alcohol
Chapter 22. Caffeine
Chapter 23. Developmental Neurotoxicity of Abused Drugs
Chapter 24. Effects of Alcohol on Embryo/Fetal Development
Chapter 25. Cigarette Smoking and Reproductive and Developmental Toxicity
• Section VI. Pharmaceuticals and Food Additives
Chapter 26. Thalidomide
Chapter 27. Retinoids
Chapter 28. Melamine and Cyanuric Acid
Chapter 29. Ionophores
• Section VII. Metals
Chapter 30. Boron
Chapter 31. Arsenic, Cadmium, and Lead
Chapter 32. Manganese
Chapter 33. Mercury
Chapter 34. Selenium
• Section VIII. Pesticides, Industrial and Other Environmental Contaminants
Chapter 35. Organophosphates and Carbamates
Chapter 36. Chlorinated Hydrocarbons and Pyrethrins/Pyrethroids
Chapter 37. Herbicides and Fungicides
Chapter 38. Brominated Flame Retardants
Chapter 39. Polychlorinated Biphenyls, Polybrominated Biphenyls, Polychlorinated Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans
Chapter 40. Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons
Chapter 41. Toxicity and Risk Assessment of Bisphenol A
Chapter 42. Ethylene Glycol
Chapter 43. Perfluorooctane Sulfonate and Perfluorooctanoic Acid
Chapter 44. Phthalates
Chapter 45. Personal Care Products and Cosmetics
• Section IX. Phytotoxicants, Mycotoxins and Zootoxins
Chapter 46. Toxic plants
Chapter 47. Fumonisins
Chapter 48. Aflatoxins, Ochratoxins, and Citrinin
Chapter 49. Zootoxins
• Section X. Special Topics
Chapter 50. Systems Toxicology and Predictive Modeling of Male Developmental Toxicity
Chapter 51. Stem Cells in Developmental Toxicity Testing
Chapter 52. Epigenetics in Reproduction and Development
Chapter 53. Mitochondrial Dysfunction in Reproductive and Developmental Toxicity
Chapter 54. Cell Signaling Mechanisms in Developmental Neurotoxicity
Chapter 55. Neuroinflammation and Oxidative Injury in Developmental Neurotoxicity
Chapter 56. Effects of Stress on Reproductive and Developmental Biology
Chapter 57. Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity
• Section XI. Endocrine Disruption, Mutagenicity, Carcinogenicity, Infertility and Teratogenicity
Chapter 58. Endocrine Disruption
Chapter 59. Developmental and Reproductive Disorders-Role of Endocrine Disruptors in Testicular Toxicity
Chapter 60. Mutagenicity and Carcinogenicity: Human Reproductive Cancer and Risk Factors
Chapter 61. Environmental Pollutants and Neural Tube Defects
Chapter 62. Teratogenicity
Chapter 63. Micro-Computed Tomography and Volumetric Imaging in Developmental Toxicology
• Section XII. Toxicologic Pathology
Chapter 64. Toxicologic Pathology of the Reproductive System
• Section XIII. Placental Toxicity
Chapter 65. The Placental Role in Developmental Programming
Chapter 66. Strategies for Investigating Hemochorial Placentation
Chapter 67. The Significance of ABC Transporters in Human Placenta for the Exposure of Fetus to Xenobiotics
Chapter 68. Placental Toxicity
Chapter 69. Placental Pathology
• Section XIV. Domestic and Wildlife Species
Chapter 70. Reproductive and Developmental Toxicity in Avian Species
Chapter 71. Endocrine Disruption in Wildlife Species
Chapter 72. Teratogenesis in Livestock

Features:
• Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development
• Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment
• Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Author
Ramesh C. Gupta, DVM, MVSc, PhD, DABT, FACT, FACN, FATS, Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA