SHORT COURSE BREAST RADIOTHERAPY. A COMPREHENSIVE REVIEW OF HYPOFRACTIONATION, PARTIAL BREAST, AND INTRA-OPERATIVE IRRADIATION

Table of contents (30 chapters)
1. APBI: History, Rationale, and Controversies
2. Pathological Anatomy of Early-Stage Breast Cancer: Defining the Target
3. The Radiobiology of Breast Radiotherapy
4. Quality Assurance and Radiation Safety for Breast Irradiation
5. Surgical Considerations in Partial-Breast Irradiation
6. Impact of Oncoplastic Surgery on Adjuvant Radiation Therapy
7. Comparison of True Cost Between Modalities in a Changing American Healthcare System
8. Patient Selection for Hypofractionated Whole Breast Radiation Therapy for Treatment of Early-Stage Breast Cancer
9. Physics of Hypofractionated Whole Breast Irradiation
10. New York University Experience and Prone Positioning
11. The Canadian Experience with Hypofractionation
12. United Kingdom Experience: Clinical Trial Evolution, Techniques, Data, and Toxicity
13. Patient Selection for Accelerated Partial Breast Irradiation (APBI)
14. Physics of APBI
15. Overview of Outcomes with Accelerated Partial Breast Irradiation
16. The Evolution of Brachytherapy Techniques and the Current Arizona Approach
17. Intracavitary Brachytherapy: Techniques, Data, Toxicity
18. External-Beam Accelerated Partial Breast Irradiation
19. Patient Selection for IORT
20. Physics of Intraoperative Radiotherapy for the Breast
21. A Risk-Adapted Approach to Breast Radiation Using Targeted Intraoperative Radiotherapy (TARGIT)
22. Intraoperative Technique with Electrons
23. Ultrashort Courses of Breast Radiotherapy
24. Breast Conservation Therapy Without Capsular Contracture in Augmented Women Using Interstitial Brachytherapy
25. Noninvasive Image-Guided Breast Brachytherapy (NIBB)
26. APBI (Accelerated Partial Breast Irradiation) for in Breast Recurrence Following WBI
27. Preoperative Partial Breast
28. Hypofractionated Regional Nodal Irradiation for Breast Cancer
29. Stereotactic Treatment for Oligometastatic Breast Cancer
30. Hypofractionated Palliative Radiation Therapy for Breast Cancer

• Focuses on the use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer
• Provides comprehensive coverage of techniques and clinical implementation, spanning partial and whole breast treatment approaches
• Written and edited by leaders in radiotherapy treatment techniques

This comprehensive handbook on the implementation of short course radiotherapy for the treatment of breast cancer is intended as an up-to-date resource for the clinician. The book opens with a series of chapters on underlying principles and diverse relevant topics, including pathologic anatomy of early-stage breast cancer, radiobiology of accelerated breast irradiation, quality assurance and radiation safety, surgical considerations in partial breast irradiation, and impact of oncoplastic surgery on adjuvant radiotherapy. Individual sections are then devoted to hypofractionated whole breast radiotherapy, accelerated partial breast irradiation, and intraoperative radiotherapy. Each section includes details of patient selection, physics, techniques, data, and toxicity. The reader is provided with clear guidance on the appropriate use of accelerated forms of adjuvant radiotherapy for treatment of early-stage breast cancer and on various emerging treatment approaches.

Authors
• Dr. Arthur is currently Professor and Vice Chairman of the Department of Radiation Oncology , Virginia Commonwealth University. His clinical and research interests include brachytherapy, management of breast and genitourinary malignancies, and soft tissue malignancies. Dr Arthur’s primary research interests include clinical studies focusing on the treatment of breast cancer with special interest in the development and use of accelerated treatment for breast cancer. He is a breast committee member of the NRG Oncology national cooperative trial group.
• Dr. Frank Vicini has held multiple academic appointments and authored over 200 peer-reviewed articles. He is involved in numerous clinical studies being the Principal Investigator of several with the goal of improving therapeutic outcomes for all stages of breast cancer, reducing cancer treatment times and minimizing toxicities of healthy tissues and vital organs. He is also listed as one of the few oncologists in "Best Oncology Doctors in America."
• David E. Wazer, MD is chief of radiation oncology for the Lifespan Healthcare System in New England and divides his time between Rhode Island Hospital and Tufts Medical Center in Boston. He is professor and chairman of radiation oncology at both Tufts University School of Medicine and The Alpert Medical School of Brown University. Dr. Wazer has numerous scientific publications, co-edits the premier textbook for radiation oncology, serves as Editor-in-Chief of the American Journal of Clinical Oncology, and actively conducts clinical and cost/utility research in breast cancer, brachytherapy, melanoma, and several novel radiation therapy technologies.
• Dr. Khan has been at the Cancer Institute of New Jersey since 2007 after completing a fellowship in brachytherapy at the Brigham and Women’s Hospital at Harvard. Prior to that, he completed a residency in radiation oncology at Rush University Medical Center. Dr. Khan’s primary focus has been in breast cancer, as well as radiation therapy for central nervous system/brain tumors. Dr Khan is interested in the discovery of novel radiosensitizers and in advanced modalities of highly conformal radiotherapy, such as image-guided brachytherapy and proton therapy.