2. Law of Poiseuille
3. Bernoulli’s Equation
5. Arterial Stenosis
8. Oscillatory Flow Theory
9. Law of Laplace
12. Wave Travel and Reflection
13. Cardiac Muscle Mechanics
14. The Pressure-Volume Relation
15. The Pump Function Graph
16. Cardiac Work, Energy and Power
17. Cardiac Oxygen Consumption and Hemodynamics
18. Cardiac Power and Ventriculo-Arterial Coupling
19. Coronary Hemodynamics
20. Assessing Ventricular Function
21. Wave Travel and Pulse Wave Velocity
22. Wave Separation and Waveform Analysis
23. Wave Intensity Analysis
24. Arterial Input Impedance
25. The Arterial Windkessel
26. Distributed Models and Tube Models
27. Transfer of Pressure
28. Pulmonary Hemodynamics
29. Mechanotransduction and Vascular Remodeling
30. Blood Flow and Arterial Disease
31. Determinants of Pressure and Flow
32. Comparative Physiology
This book is written in a quick reference style to help clinical and basic researchers, as well as graduate students, in the understanding of hemodynamics. Recent dev- opments in genetics and molecular biology on the one hand, and new noninvasive measurement techniques on the other hand, make it possible to measure and und- stand the hemodynamics of heart and vessels better than ever before. Hemodynamics makes it possible to characterize, in a quantitative way, and even with noninvasive techniques the function of the heart and the arterial system, separately and in c- bination, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. We have made the layout of the book such that it gives a succinct overview of individual topics in short chapters Therefore every chapter starts with a “box” c- taining a figure and caption, describing the main aspects of the subject. It is often sufficient to study the contents of this box alone to obtain this basic information, and therefore it is not necessary to read the book from cover to cover.
• I Extra chapters on Ventriculo-arterial coupling
• Updated text and 164 color illustrations
• Nicolaas Westerhof is a Professor Emeritus of Physiology based at VU University Medical Center, Amsterdam where his fields of interest include cardiovascular hemodynamics. He received his Ph.D. from the University of Pennsylvania, Philadelphia, PA. He was director of the Institute for Cardiovascular Research at VUMC (now Amsterdam Cardiovascular Sciences). Nico Westerhof is a knight in the Order of the Lion of the Netherlands. He received an Honorary Doctorate from the Ecole Polytechnique Fédérale de Lausanne, Switzerland; the ‘Oeuvre-prize’ of the Netherlands Society of Physiology and the ‘Lifetime Achievement Award’ of ARTERY Society.
• Nikos Stergiopulos is Director of the Laboratory of Hemodynamics and Cardiovascular Technology (LHTC), part of the Ecole Polytechnique Federale de Lausanne in Switzerland. His fields of interest include arterial wall mechanics, vascular remodeling, atherogenesis and restenosis, arterial wave propagation, heart-arterial system interaction, cardiac mechanics, angioplasty & stenting and implantable devices.
• Professor Noble is Honorary Professor of Cardiovascular Medicine, Aberdeen University. He is a fellow of the Royal College of Medicine of London, the European Society of Cardiology, the Royal Society of Medicine and the Association of Physicians. He has also held the prestigious visiting professorships of Boerhaave Professor of Medicine, at the University of Leiden. And Spinola Professor of Medicine, at the University of Amsterdam. His last position in the University of London was that of Professor of Cardiovascular Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London.
• Berend E. Westerhof is interested in the quantitative description of the cardiovascular system including the hemodynamics of the systemic- as well as the pulmonary circulation. His further interests include hemodynamic monitoring, signal analysis and the use of mathematical modeling. He received his M.S degree of Delft University and Ph.D. from the University of Amsterdam. He worked several years in industry and is presently back in academia.