STEM CELLS IN TOXICOLOGY AND MEDICINE

• PART I 1
1 Introduction 3
2 Application of Stem Cells and iPS Cells in Toxicology 5
3 Stem Cells: A Potential Source for High Throughput Screening in Toxicology 26
4 Human Pluripotent Stem Cells for Toxicological Screening 50
5 Effects of Culture Conditions on Maturation of Stem Cell-Derived Cardiomyocytes 71
6 Human Stem Cell-Derived Cardiomyocyte In Vitro Models for Cardiotoxicity Screening 85
7 Disease-Specific Stem Cell Models for Toxicological Screenings and Drug Development 122
8 Three-Dimensional Culture Systems and Humanized Liver Models Using Hepatic Stem Cells for Enhanced Toxicity Assessment 145
9 Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment 155
10 A Human Stem Cell Model for Creating Placental Syncytiotrophoblast, the Major Cellular Barrier that Limits Fetal Exposure to Xenobiotics 179
11 The Effects of Endocrine Disruptors on Mesenchymal Stem Cells 196
12 Epigenetic Landscape in Embryonic Stem Cells 238
• PART II 247
13 The Effect of Human Pluripotent Stem Cell Platforms on Preclinical Drug Development 249
14 Generation and Application of 3D Culture Systems in Human Drug Discovery and Medicine 265
15 Characterization and Therapeutic Uses of Adult Mesenchymal Stem Cells 288
16 Stem Cell Therapeutics for Cardiovascular Diseases 303
17 Stem-Cell-Based Therapies for Vascular Regeneration in Peripheral Artery Diseases 324
18 Gene Modified Stem/Progenitor-Cell Therapy for Ischemic Stroke 347
19 Role of Stem Cells in the Gastrointestinal Tract and in the Development of Cancer 363
20 Cancer Stem Cells: Concept, Significance, and Management 375
21 Stem Cell Signaling in the Heterogeneous Development of Medulloblastoma 414
22 Induced Pluripotent Stem Cell-Derived Outer-Blood-Retinal Barrier for Disease Modeling and Drug Discovery 436
23 Important Considerations in the Therapeutic Application of Stem Cells in Bone Healing and Regeneration 458
24 Stem Cells from Human Dental Tissue for Regenerative Medicine 481
25 Stem Cells in the Skin 502

A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine

• Presented by internationally recognized investigators in this exciting field of scientific research
• Provides an insight into the current trends and future directions of research in this rapidly developing new field
• A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government