STEREOTACTIC AND FUNCTIONAL NEUROSURGERY. PRINCIPLES AND APPLICATIONS

1. Traditional and Mini-Frames
2. Stereotactic Robots
3. Intraoperative Magnetic Resonance Imaging and Computed Tomography
4. Frameless Image Guidance in Stereotactic Radiosurgery
5. Principles of Safe Stereotactic Trajectories
6. Structural Imaging and Target Visualization
7. Network-Based Imaging and Connectomics
8. Microelectrode Recording in Neurosurgical Patients
9. Local Field Potentials and ECoG
10. Awake Testing to Confirm Target Engagement
11. Cloud-Based Stereotactic and Functional Neurosurgery and Registries
12. Responsive Neurostimulation
13. Spinal Stimulation
14. Peripheral Nerve Stimulation
15. Non-invasive Central Neuromodulation with Transcranial Magnetic Stimulation
16. Ablation: Radiofrequency, Laser, and HIFU
17. Radiosurgery
18. Parkinson""s Disease: Deep Brain Stimulation
19. Parkinson""s Disease: Lesions
20. Essential Tremor: Deep Brain Stimulation
21. Essential Tremor: Lesions
22. Dystonia
23. Epilepsy: Invasive Monitoring
24. Epilepsy: Mesial Temporal
25. Epilepsy: Neocortical
26. Pediatric Epilepsy
27. Epilepsy: Neuromodulation
28. Treatment-Resistant Depression: Deep Brain Stimulation
29. Obsessive-Compulsive Disorder: Deep Brain Stimulation
30. Obsessive-Compulsive Disorder: Lesions
31. Gilles de la Tourette Syndrome: Deep Brain Stimulation
32. Chronic Pain: Neuromodulation
33. Chronic Pain: Lesions
34. Cluster Headache: Deep Brain Stimulation
35. Developing New Indications: Strategies and Hurdles to Discovery
36. Imaging: Patient Selection, Targeting, and Outcome Biomarkers
37. The Design of Clinical Studies for Neuromodulation
38. Registries and Big Data

This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options.
Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

Features
• Practical, clinically-relevant, and balanced in presentation
• Combines coverage of traditional methods with state-of-the-art technology
• Written by experts in each area

Authors
• Nader Pouratian, MD, PhD. Professor and Vice Chair, Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
• Sameer A. Sheth, MD, PhDAssociate Professor, Vice-Chair of Clinical Research, McNair Scholar, Department of Neurosurgery, Baylor College of MedicineHouston, TX, USA