STROKE GENETICS. 2ND EDITION

1. Introduction
2. Familial Occurrence and Heritability of Stroke
3. Genetic Association Studies and Next Generation Sequencing in Stroke: Methods
4. The Genetics of Cerebral Aneurysms and Other Vascular Malformations
5. Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy
6. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)
7. Monogenic Disorder: Fabry Disease
8. Stroke-Like Episodes in Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes (MELAS)
9. Sickle Cell Disease
10. Other Monogenetic Stroke Disorders
11. White Matter Disease
12. Genetics of Carotid Disease
13. Genetics of Cervical Artery Dissection
14. Genetics of Small Vessel Disease
15. Non-Caucasian Stroke Genetics
16. Cerebral Venous Thrombosis: Genetic Aspects
17. Stroke Pharmacogenetics
18. Genetic Research and the Law

This revised, expanded second edition updates the reader on this fast moving field as well providing an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genomewide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.
Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

Features
• Discusses important and novel results from large datasets, as genetics has continued to advance at an unprecedented rate since the first edition
• Includes new chapters on nonCaucasian stroke, advanced imaging and cerebral venous thrombosis-
• Written by international experts who have been intimately involved in unraveling the genetic etiology of stroke

Authors
• Pankaj Sharma, MD, PhD, FRCP. Reader & Consultant Neurologist. Imperial College London & Hammersmith Hospitals. London, UK
• James F. Meschia, MD. Chair, Department of Neurology. Mayo Clinic. Jacksonville, Florida, USA