FISCHER, J.; KLEIN, C.; CHILDERS, W.
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133,00 €GENERAL ASPECTS
Drug Discovery in Academia
Intracellular Degraders and Other Small Molecules Targeting Protein-Protein Interactions
DRUG CLASS STUDIES
CGRP Blockers for Migraine Treatment
GLP-1 Agonists
Oligonucleotide Therapeutics
CART-T Therapy
SGLT2 Inhibitors
CASE STUDIES
Emicizumab
Ivosidenib
Ribociclib
Following the successful approach of the previous volumes in the series, the inventors and primary developers of drugs that made it to the market tell the story of the drug's discovery and development and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed drug. After a general section that addresses overarching topics for drug discovery, 8 selected case studies of individual drugs or drug classes describe recently introduced drugs, encompassing small molecules, antibodies and oligonucleotides, thereby providing a representative cross-section of the present-day drug development effort. Backed up by lots of data and chemical information, the insight and experience of the best contemporary drug creators turns this book into one of the most useful training manuals that a junior medicinal chemist can hope to find.
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