SYSTEMS BIOLOGY

1 Integrative Analysis of Omics Data 1
2 13C Flux Analysis in Biotechnology and Medicine 25
3 Metabolic Modeling for Design of Cell Factories 71
4 Genome-Scale Metabolic Modeling and In silico Strain Design of Escherichia coli 109
5 Accelerating the Drug Development Pipeline with Genome-Scale Metabolic Network Reconstructions 139
6 Computational Modeling of Microbial Communities 163
7 Drug Targeting of the Human Microbiome 191
8 Toward Genome-Scale Models of Signal Transduction Networks 215
9 Systems Biology of Aging 243
10 Modeling the Dynamics of the Immune Response 265
11 Dynamics of Signal Transduction in Single Cells Quantified by Microscopy 289
12 Image-Based In silico Models of Organogenesis 319
13 Progress toward Quantitative Design Principles of Multicellular Systems 341
14 Precision Genome Editing for Systems Biology – A Temporal Perspective 367

Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems.

Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression.

This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.