TARGETING CANCER (COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY LXXXI). SOFTCOVER

• Cancer Stem Cells
Normal and Neoplastic Stem Cells
Targeting the Epithelial-to-Mesenchymal Transition: The Case for Differentiation-Based Therapy
Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations
Cell of Origin and Cancer Stem Cells in Tumor Suppressor Mouse Models of Glioblastoma
• Genetics and Epigenetics
The Enigma of p53
Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome
Composition and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Disease
The Essential Transcriptional Function of BRD4 in Acute Myeloid Leukemia
• Metabolism
Reexamining How Cancer Cells Exploit the Body's Metabolic Resources
Autophagy, Metabolism, and Cancer
A Time for MYC: Metabolism and Therapy
Beyond the Oncogene Revolution: Four New Ways to Combat Cancer
Lipid Synthesis Is a Metabolic Liability of Non-Small Cell Lung Cancer
• Targets, Vaccines, and Therapeutics
Cancer Immunogenomics: Computational Neoantigen Identification and Vaccine Design
Targeting HIF2 in Clear Cell Renal Cell Carcinoma
BET Bromodomain Proteins as Cancer Therapeutic Targets
To Prime, or Not to Prime: That Is the Question
Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer
• Microenvironment and Metastasis
Tumor-Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications
Cancer, Oxidative Stress, and Metastasis
RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers
Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis
• Models of Cancer
Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets
Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities
Modeling Breast Cancer Intertumor and Intratumour Heterogeneity Using Xenografts
Challenges and Opportunities in Modeling Pancreatic Cancer
• Cancer Genomics and Tumor Heterogeneity
Functional Genomic Characterization of Cancer Genomes
How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually ?Exclusive Oncogenic Mutations?
A Pipeline for Drug Target Identification and Validation
Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity
Discovery of Double-Stranded Genomic DNA in Circulating Exosomes
?Summary

The 81st Cold Spring Harbor Symposium focused on Targeting Cancer. The implications of how the underlying science can drive improvements in diagnostic, prognostic, and therapeutic approaches was a major theme throughout the Symposium. The topics covered at the meeting included: Cancer Genes and Genomes; Cancer Pathways; Tumor Cell Biology; Cancer Growth & Progression; Innate & Adaptive Immune Responses; and Enabling Technologies. Several speakers participated in interviews during the course of the Symposium week and transcripts of those videos and the Dorcas Cummings lecture are included.