TECHNICAL ASPECTS OF FOCAL THERAPY IN LOCALIZED PROSTATE CANCER

•The first book to focus on the state of art of overall focal therapy techniques
•The first book to address this topic in depth
•Presents contributions by the world’s best teams involved in this new therapy development

Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy.
These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity.
As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure.
Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

Authors
Dr Eric Barret is a well-known urologist at Montsouris Institut in Paris, France and Dr Matthieu Durand is an urologist at Nice University hospital in France and specialist in cryotherapy. Prof. Guy Vallancien (Institut Montsouris, Paris, France) will write the Foreword. He is head of urology department at Montsouris Institut, Professor at Paris Descartes University, President of the European School of Surgery and Member of the Executive Committee of the French Urological Association.

Table of contents (20 chapters)
1.Rationale for Focal Therapy
2.The Concept of the Index Lesion
3.Definitions and Principles of Focal Therapy
4.Patient Selection for Focal Therapy for Prostate Cancer
5.Role and Technique of Transrectal Ultrasound for Focal Therapy
6.Magnetic Resonance Imaging for Patient Selection for Focal Therapy
7.Prostate Histoscanning
8.Elastography for Prostate Cancer
9.Assessment of Tissue Destruction After Focal Therapy
10.Transperineal Template-guided Mapping Biopsy of the Prostate
11.Focal Cryotherapy
12.Focal High-Intensity Focused Ultrasound (HIFU)
13.Focal Brachytherapy
14.Focal Photodynamic Therapy
15.Focal Laser Interstitial Thermotherapy
16.Emerging Energies for Focal Ablation of Prostate Cancer
17.Technical Aspects of Focal Therapy in Localized Prostate Cancer: Follow-Up After Focal Therapy
18.Failure or Recurrence Management
19.Salvage Focal Therapy for Prostate Cancer
20.Focal Therapy: Current Status and Future Directions