TEXTBOOK OF DIABETES. 6TH EDITION

List of Contributors, viii
Preface, xv
List of Abbreviations, xvi
• Part 1 Diabetes in its Historical and Social Context
1 The History of Diabetes Mellitus, 3
2 Classification and Diagnosis of Diabetes, 22
3 The Global Burden of Diabetes, 28
4 Epidemiology of Type 1 Diabetes, 41
5 Epidemiology of Type 2 Diabetes, 55
• Part 2 Normal Physiology
6 Overview of Glucose Metabolism, 77
7 Islet Function and Insulin Secretion, 84
8 Glucagon in Islet and Metabolic Regulation, 99
9 Mechanism of Insulin Action, 111
10 Central Control of Glucose Homeostasis, 128
11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142
• Part 3 Pathogenesis of Diabetes
12 The Genetics of Diabetes, 157
13 Genetics of Obesity, 197
14 Autoimmune Type 1 Diabetes, 203
15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216
16 Abnormalities of Insulin Secretion and ß-Cell Defects in Type 2 Diabetes, 225
17 Insulin Resistance in Type 2 Diabetes, 238
18 Obesity and Diabetes, 250
19 The Microbiome and Diabetes, 261
• Part 4 Other Types of Diabetes
20 Monogenic Causes of Diabetes, 275
21 Drug-Induced Diabetes, 295
22 Diabetes in Hypersecreting Endocrine Disorders, 304
23 Pancreatic Disease and Diabetes, 319
24 Clinical Presentations of Diabetes, 330
• Part 5 Managing the Person with Diabetes
25 The Aims of Diabetes Care, 343
26 Education to Empower the Person with Diabetes, 354
27 Dietary Management of Diabetes, 368
28 Physical Activities and Diabetes, 382
29 Monitoring Diabetes, 404
30 Biomarkers and Precision Medicine in Diabetes, 414
• Part 6 Treatment of Diabetes
31 Insulin and Insulin Treatment, 431
32 New Technologies for Glucose Monitoring, 444
33 New Technologies for Insulin Administration, 459
34 Whole Pancreas and Islet Cell Transplantation, 473
35 Oral Glucose-Lowering Agents, 492
36 Non-insulin Parenteral Therapies, 520
37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534
38 Weight Management and Metabolic Surgery, 551
39 In-Hospital Treatment and Surgery in People with Diabetes, 559
40 Hypoglycaemia in Diabetes, 579
41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602
• Part 7 Microvascular Complications in Diabetes
42 Pathogenesis of Microvascular Complications, 615
43 Diabetic Retinopathy, 629
44 Diabetic Nephropathy, 640
45 Diabetic Neuropathy, 655
• Part 8 Macrovascular Complications in Diabetes
46 Pathogenesis of Macrovascular Complications in Diabetes, 681
47 Hypertension and Diabetes, 700
48 Dyslipidaemia and Diabetes, 713
49 Ischaemic Heart Disease in Diabetes, 724
50 Heart Failure and Diabetes, 732
51 Cerebrovascular Disease and Diabetes, 745
52 Peripheral Vascular Disease, 755
• Part 9 Other Complications of Diabetes
53 Foot Problems in People with Diabetes, 771
54 Sexual Function in Men and Women with Diabetes, 780
55 Gastrointestinal Manifestations of Diabetes, 796
56 Diabetes and Oral Health, 810
57 Diabetes and Non-alcoholic Fatty Liver Disease, 820
58 The Skin in Diabetes, 838
59 Bone and Rheumatic Disorders in Diabetes, 853
60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867
61 Diabetes and Infections, 878
62 Sleep and Diabetes, 897
• Part 10 Psychosocial Aspects of Diabetes
63 Psychosocial and Behavioural Aspects of Diabetes, 907
64 Role of Cognitive Function in Managing People with Diabetes, 922
65 Mental Disorders and Diabetes, 933
66 Social Aspects of Diabetes, 956
67 Social Determinants of Diabetes, 973
• Part 11 Diabetes in Special Groups
68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987
69 Diabetes in Childhood, 999
70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019
71 Diabetes in Pregnancy, 1034
72 Diabetes in Old Age, 1072
73 Diabetes at the End of Life, 1085
• Part 12 Delivery and Organization of Diabetes Care
74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097
75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107
• Part 13 Future Directions
76 Immunotherapies for Type 1 Diabetes, 1125
77 Stem Cell Therapy in Diabetes, 1137
78 Gene Therapy for Diabetes, 1144
79 Future Drug Treatments for Type 2 Diabetes, 1154
Index, 1167

Classic textbook providing diabetologists and endocrinologists with illustrated and clinically focused content on diabetes.

Now in its sixth edition, the Textbook of Diabetes has established itself as the modern, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the textbook hosts an unrivalled blend of clinical and scientific content. Written by highly experienced editors and international contributors all of whom have provided insight on new developments in diabetes care. These include the most recent guidelines from the European Association for the Study of Diabetes (EASD), the American Diabetes Association (ADA), Diabetes UK, and the National Institute for Health and Care Excellence (NICE) and information on the latest treatment modalities used around the world.

The textbook includes free access to the Wiley Digital Edition which provides easy-to-use searching across the book, the full reference list with web links, illustrations and photographs, and post-publication updates.

Sample topics covered in Textbook of Diabetes include:
• Diabetes in its historical and social context, covering the history of diabetes, past classification and diagnosis of diabetes and the global burden of diabetes
• Normal physiology, covering glucose homeostasis, islet function and insulin secretion, and glucagon in islet and metabolic regulation
• Pathogenesis of diabetes, covering genetics of diabetes and obesity, autoimmune type 1 diabetes and other disorders with type 1 diabetes phenotype
• Other types of diabetes, covering endocrine disorders that cause diabetes, pancreatic diseases and diabetes and drug-induced diabetes

Beautifully illustrated with a clinical focus, Textbook of Diabetes provides endocrinologists and diabetologists, both consultants/specialists and those in training, with a fresh and comprehensive clinical resource to consult time and time again. The text is also of value to specialist diabetes nurses and researchers in the field.

Authors
• Richard I.G. Holt, Professor in Diabetes and Endocrinology, University of Southampton, UK and Honorary Consultant Physician, University Hospital Southampton NHS Foundation Trust. Professor Holt is also Chair of the EASD Committee for Clinical Affairs.
• Allan Flyvbjerg, Former CEO at Steno Diabetes Center Copenhagen and Clinical Professor at University of Copenhagen, Denmark. Further, professor Flyvbjerg was President of the Danish Diabetes Association from 2000-2011 and is presently member of the Board of Directors of EASD, Chairman of the EASD Postgraduate Education Committee and Chairman of the Board of Directors of The Danish Diabetes and Endocrine Academy (DDEA).