TEXTBOOK OF UNCOMMON CANCER, FIFTH EDITION

• Section 1 General Principles of Care of Uncommon Cancers
1 A Structured Approach to Uncommon Cancers 1
2 What Patients Need to Know: Information Needs and Information Sources of Patients Diagnosed with Rare Cancers 6
3 Involving the Public in Rare Cancer Care and Research: Shaping the Future for Rare and Uncommon Cancers 12
• Section 2 Genitourinary Cancers
4 Uncommon Tumors of the Kidney 19
5 Uncommon Cancers of the Bladder 41
6 Urethral Cancer 54
7 Uncommon Cancers of the Prostate 68
8 Rare Tumors of the Testis and Paratesticular Tissues 97
9 Penile Carcinoma 122
• Section 3 Head and Neck
10 Uncommon Tumors of the Oral Cavity and Adjacent Structures 134
11 Rare Tumors of the Larynx 152
12 Nasopharyngeal Carcinoma in Nonendemic Populations 165
13 Esthesioneuroblastoma 196
• Section 4 Thoracic Tumors
14 Thymoma and Thymic Carcinoma 214
15 Primary Sarcomas of the Lung 248
16 Mesothelioma 266
17 Primary Melanoma of the Lung 285
18 Large Cell Neuroendocrine Carcinoma 293
19 Lung Adenocarcinoma: Current Classifications and Uncommon Mutations 305
20 Primary Adenoid Cystic Carcinoma of the Lung 315
• Section 5 Breast Cancers
21 Metaplastic Breast Cancer 327
22 Tubular Carcinoma of the Breast 338
23 Breast Sarcoma 345
24 Adenoid Cystic Carcinoma of the Breast 357
25 Breast Cancer in Men 364
• Section 6 Gastrointestinal Tumors
26 Uncommon Tumors of the Esophagus 377
27 Uncommon Cancers of the Stomach 395
28 Uncommon Cancers of the Small Bowel 416
29 Uncommon Cancers of the Pancreas 429
30 Uncommon Hepatobiliary Tumors 444
31 Unusual Tumors of the Colon, Rectum, and Anus 458
32 Gastrointestinal Stromal Tumors 470
• Section 7 Gynecological Cancers
33 Surgery for Uncommon Gynecological Cancers 493
34 Histologies That Cross Organ Types 508
35 Germ Cell Tumors of the Ovary 518
36 Sex Cord Stromal Tumors of the Ovary 533
37 Clear Cell Carcinoma of the Ovary 550
38 Mucinous Carcinoma of the Ovary 557
39 Low-Grade Serous Carcinoma of the Ovary 564
40 Borderline Tumors of the Ovary 572
41 Fallopian Tube and Peritoneal Cancers 582
42 Nonendometrioid Endometrial Carcinomas and Uterine Sarcomas 591
43 Tumors of the Cervix 618
44 Tumors of the Vulva and Vagina 643
45 Gestational Trophoblastic Disease 653
46 Targeted Therapy in Gynecological Malignancy 663
• Section 8 Endocrine Tumors
47 Adrenal Neoplasms 681
48 Uncommon Cancers of the Thyroid 713
49 Parathyroid Carcinoma 730
• Section 9 Hematological Malignancies
50 Rare Acute Leukemias 740
51 Unusual Myelodysplastic and Myelodysplastic/Myeloproliferative Neoplasms 752
52 Rare B Cell Lymphoproliferative Disorders 760
53 Uncommon Presentations of Plasma Cell Dyscrasias 776
54 Rare Bone Marrow Failure Conditions 793
55 Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis 816
56 Rare T Cell Lymphomas 830
• Section 10 Neurological Tumors
57 Primary Melanotic Tumors of the Central Nervous System 840
58 Comprehensive Management of Chordoma 847
59 Atypical and Malignant Meningiomas 856
60 Primary Central Nervous System Lymphoma 871
61 Choroid Plexus Tumors 883
62 Diffuse Low-Grade Gliomas 888
63 High-Grade Gliomas 899
64 Ependymomas 907
65 Medulloblastoma in Adults 917
66 Pineal Parenchymal Tumors 939
67 Craniopharyngiomas 949
68 Ophthalmic Cancers 964
• Section 11 Cutaneous Malignancies
69 Unusual Cutaneous Malignancies 976
70 Dermatofibrosarcoma Protuberans 994
71 Unusual Melanomas 1002
• Section 12 Musculoskeletal Tumors
72 Uncommon Tumors of Soft Tissue 1022
• Section 13 Pediatric Cancers
73 Introduction to Rare Pediatric Malignancies 1077
74 Uncommon Tumors of the Gastrointestinal Tract in Children 1080
75 Rare Pediatric Malignancies of the Head and Neck 1096
76 Uncommon Pediatric Tumors of the Thorax 1105
77 Uncommon Adrenal Tumors in Children and Adolescents 1134
78 Uncommon Pediatric Genitourinary Tumors 1146
79 Uncommon Pediatric Brain Tumors 1160
80 Malignant Tumors of the Skin and Subcutaneous Tissue in Children 1180
81 Rare Hematological Malignancies in Children 1198

The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist.

• Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce
• Fully revised with new material and an evidence-based, teach-by-example approach
• Provides insight on real-world decision making in the clinical setting
• Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview
• Extensively illustrated in full color throughout, including heat maps to show gene expression

Author Information
• Derek Raghavan, MD, PhD, FACP, FRACP, FASCO. President, Levine Cancer Institute, Carolinas HealthCare System; Professor of Medicine, University of North Carolina School of Medicine, Charlotte, North Carolina, USA.
• Manmeet S. Ahluwalia, MD, FACP. Dean and Diane Miller Family Endowed Chair in Neuro-Oncology, Head of Operations, Director, Brain Metastasis Research Program; Associate Director, Clinical Trials, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic; Associate Professor, Department of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.
• Charles D. Blanke, MD, FACP, FASCO. Professor of Medicine, Division of Hematology and Medical Oncology, Knight Cancer Institute, Portland, Oregon, USA.
• Jubilee Brown, MD. Professor and Associate Director of Gynecologic Oncology, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, USA.
• Edward S. Kim, MD, FACP. Chair, Department of Solid Tumor Oncology and Investigational Therapeutics; Donald S. Kim Distinguished Chair for Cancer Research, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, North Carolina, USA.
• Gregory H. Reaman, MD. Professor of Pediatrics, George Washington University School of Medicine and Health Sciences; Center for Cancer and Blood Disorders, Children's National Health System, Washington, District of Columbia, USA.
• Mikkael A. Sekeres, MD, MS. Director, Leukemia Program and Professor of Medicine, Cleveland Clinic, Cleveland, Ohio, USA.