THE BRAIN ADAPTING WITH PAIN. CONTRIBUTION OF NEUROIMAGING TECHNOLOGY TO PAIN MECHANISMS

Ideal for anyone with an interest in the increasing role of brain imaging in understanding pain perception and pain mechanisms, this unique, full-color resource thoroughly covers technical advances in the field as well as potential new applications. Dozens of worldwide experts first demystify the technological concepts that are crucial for proper understanding and interpretation of neuroimaging findings, then explore new advances in understanding brain mechanisms of pain, in human as well as animal models.

Key Features:
- Covers key topics in the field, including the historical perspective, technology, animal pain neuroimaging, acute pain, neuroplasticity of chronic pain, chronic pain, pain modulation, ethical conflicts, and future directions
- Highlights strengths and weaknesses of specific neuroimaging techniques, and includes divergent views regarding outcomes and implications.
- Provides a short commentary from Dr. Apkarian, covering significant advances and unanswered questions.
- Ensures that both the experienced scientist and the general clinician will find the information they need to understand the current state of the field as well as potential future directions regarding the interaction between the brain and pain.
- Discusses both acute and various chronic pain conditions from a functional/physiological, structural/anatomical perspective, and evaluates the tools with which new therapies should be developed for properly treating and/or preventing pain states.

Contents
1.Brain Imaging and Pain: A Historical Perspective
2.Using Neuroimaging to Understand Pain: Pattern Recognition and the Path from Brain Mapping toMechanisms
3.Resting State Brain Signals and Functional Connectivity Mapping
4.Monitoring Brain Electrical/Magnetic Activity for Assessing Pain: Advantages and Limitations
5.The Time Frequency Pattern of Pain Processing and Pain Modulation
6.The Infrastructure of Brain Rhythms and Its Disruption in Pain
7.Modeling the Brain as a Network
8.Pain and Machine Learning
9.Modulation of Acute and Chronic Pain by Non-Invasive Stimulation: Advances and Future Potential
10.Spinal Cord fMRI to Study Pain Processing in Humans
11.Neuroimaging the Genomics of Pain Processing
12.fMRI Pain Related Brain Measures in Rodents
13.Combining Neuroimaging with Electrophysiology in Animal Studies
14.phMRI Measures of Analgesics in Preclinical Studies
15.Central Nervous System Mechanisms Supporting the Construction of an Experience of Pain Intensity
16.The “Pain Matrix”: Myths and (Unpleasant) Truths
17.The Descending Pain Modulatory System in Humans
18.Evoked Potentials in Relation to Pain Perception
19.Placebo and Activity in the Central Nervous System
20.Functional Reorganization of the Brain with Chronic Pain
21.Anatomical Reorganisation of the Brain with Chronic Pain
22.Resting State Alterations in Chronic Pain
23.Understanding Pain Mechanisms Using Rodent Brain Imaging: Opportunities and Pitfalls
24.Chronification of Back Pain: Causes and Consequences
25.Imaging Migraine
26.Chronic Visceral Pain
27.Brain Imaging and Chronic Visceral Pain
28.In Search of Pelvic Pain
29.Functional and Structural Neural Abnormalities in Temporomandibular Disorders
30.Brain Activity and Reorganization in CRPS
31.Acupuncture, Pain, and Brain Imaging
32.Controversies in the Mechanism of Central Pain
33.Pharmacological FMRI
34.Neuroethical Issues in Brain Imaging of Pain
35.Neuroimaging Current Developments and Future Uses