THE HEART IN RHEUMATIC, AUTOIMMUNE AND INFLAMMATORY DISEASES. PATHOPHYSIOLOGY, CLINICAL ASPECTS AND THERAPEUTIC APPROACHES

• Part I. Immune Medicated Cardiac Injury, Accelerated Atherosclerosis and the Study of Cardiac Involvements in Systemic Diseases
Chapter 1. Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases
Chapter 2. Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management
Chapter 3. Autoantibodies Directed Against G-Protein-Coupled Receptors in Cardiovascular Diseases: Basics and Diagnostics
Chapter 4. Immune-Mediated Accelerated Atherosclerosis
Chapter 5. A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity
• Part II. Cardiac Manifestations of Inflammatory Arthritis
Chapter 6. Rheumatoid Arthritis
Chapter 7. Juvenile Idiopathic Arthritis
Chapter 8. Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, and Reactive Arthritis
Chapter 9. Polymyalgia Rheumatica
• Part III. Cardiac Involvement in Autoimmune and Connective Tissue Diseases
Chapter 10. Systemic Lupus Erythematosus
Chapter 11. Neonatal Lupus
Chapter 12. Sjögren’s Syndrome
Chapter 13. Systemic Sclerosis
Chapter 14. Dermatomyositis and Polymyositis
• Part IV. Cardiac Manifestations Crystal-Induced Arthritis
Chapter 15. Gout
• Part V. Cardiac Manifestations of Large Vessel Vasculitides
Chapter 16. Giant Cell Arteritis
Chapter 17. Takayasu’s Arteritis
• Part VI. Cardiac Manifestations of Medium Vessel Vasculitides
Chapter 18. Polyarteritis Nodosa
Chapter 19. Kawasaki Disease
• Part VII. Cardiac Manifestations of Small Vessel Vasculitides
Chapter 20. ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis)
• Part VIII. Cardiac Manifestations of Variable Vessel Vasculitides
Chapter 21. Behçet’s Disease
• Part IX. Post-Infectious Autoimmune Cardiac Diseases
Chapter 22. Rheumatic Fever and Rheumatic Heart Disease
Chapter 23. Chagas Cardiomyopathy
• Part X. Autoinflammation
Chapter 24. Familial Mediterranean Fever
• Part XI. Therapeutic Approaches: Mechanisms of Action and Cardiac Effects
Chapter 25. Desirable and Adverse Effects of Antiinflammatory Agents on the Heart
Chapter 26. The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart
Chapter 27. Autoantibody-Directed Therapy in Cardiovascular Diseases
Chapter 28. Cardiac Immunomodulation

Features:
• A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases.
• Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches.
• Presents an up-to-date “level of evidence” and “strengths of recommendations” for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

Author
Udi Nussinovitch, Rambam Health Care Campus, affiliated to the Technion Institute of Technology, Israel