THE MICROBIOME IN RHEUMATIC DISEASES AND INFECTION

1. The Microbiome: Past, Present, and Future
2. Methods for Microbiota Analysis: Sample Collection and Laboratory Methods
3. Analytic Methods in Microbiome Studies
4. Immunodeficiency and Autoimmunity
5. Immunology of the Microbiome: Implications for Rheumatoid Arthritis and Other Autoimmune Diseases
6. Animal Models of Rheumatoid Arthritis
7. Lyme Disease: Infectious and Noninfectious Features
8. Helicobacter pylori: Immune Responses and Gastric Autoimmunity
9. Rheumatic Complications of Streptococcus pyogenes
10. Mollicutes: Mycoplasma pneumoniae
11. DNA Viruses in Autoimmune Rheumatic Diseases
12. RNA Viruses and Autoimmunity: A Short Overview
13. Autoimmunity and the Paradox of Chagas Disease
14. Macrophage Activation Syndrome
15. Rheumatoid Arthritis
16. Spondyloarthritis
17. Juvenile Idiopathic Arthritis
18. Psoriasis and Psoriatic Arthritis
19. Inflammatory Bowel Disease
20. Reactive Arthritis
21. Systemic Lupus Erythematosus
22. Antiphospholipid Syndrome
23. Sjögren’s Syndrome
24. Systemic Sclerosis
25. Systemic Vasculitides
26. Cryoglobulinemic Vasculitis
27. Behçet Disease
28. Autoinflammatory Diseases
29. Histiocytoses
30. Subacute Bacterial Endocarditis
31. Chronic Recurrent Multifocal Osteomyelitis (CRMO)
32. Vaccinations in Rheumatology
33. Management of Autoimmune and Inflammatory Disorders in the Setting of Infection or Immunodeficiency
34. Individual Drugs in Rheumatology and the Risk of Infection
35. The Promise of Personalized Medicine

This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

Features
• Offers practicing clinicians intimate knowledge of the microbiome’s role in rheumatic diseases and how this influences their daily practice
• Includes detailed basic science and immunology sections for clinicians to better understand the function of the microbiome
• Covers the role of infectious organisms in major rheumatic diseases including rheumatoid arthritis and vasculitis
• Experts from around the world offer a comprehensive and international perspective on the topic

Authors
• Gaafar Ragab, MD is Professor of Internal Medicine at Cairo University and Fellow of the American College of Rheumatology. He was previously Head of the Clinical Immunology and Rheumatology unit at Cairo University.
• T. Prescott Atkinson, MD, PhD is Professor/ Director of the Division of Pediatric Allergy, Asthma & Immunology at The Children’s Hospital of Alabama.
• Matthew L. Stoll, MD, PhD is Associate Professor in the Division of Pediatric Rheumatology at the University of Alabama at Birmingham.