THYROID CANCER. A CASE-BASED APPROACH

Table of contents (47 chapters)
1.A Patient with a Single Thyroid Nodule Suspicious for Follicular Neoplasm According to the Bethesda System for Reporting Thyroid Cytopathology: Molecular Evaluation
2.A Case of a Small (1–2 cm) Papillary Thyroid Cancer in a Young Patient: Lobectomy Versus Total Thyroidectomy
3.The Decision-Making Process for Prophylactic Central Neck Dissection in a Patient Presenting with an Indeterminate Thyroid Nodule on Cytology Assessment: Role of Preoperative Ultrasound and Molecular Marker Testing
4.Incidentally Discovered Micropapillary Thyroid Cancer
5.Completion Thyroidectomy in a Patient with Low-Risk Papillary Cancer
6.A Case of Multifocal Papillary Thyroid Microcarcinoma
7.A Papillary Thyroid Cancer with Minimal Extra-thyroidal Extension
8.A Case of a Papillary Thyroid Cancer with Lymph Node Metastases Found on Prophylactic Central Neck Dissection (Subclinical Disease, Micrometastases)
9.Papillary Thyroid Cancer with Central Neck Lymph Node Metastases
10.A Patient with a Large Minimally Invasive Follicular Thyroid Cancer
11.A Young Patient with Intrathyroidal Papillary Thyroid Cancer and Family History of Differentiated Thyroid Cancer
12.A Child with Papillary Thyroid Cancer and Locally Advanced Disease but No Distant Metastasis
13.A Patient with Papillary Thyroid Cancer and Biochemical Evidence of Disease at the One-Year Follow-Up Visit
14.Low but Detectable Suppressed Thyroglobulin Levels in the Follow-Up of Differentiated Thyroid Cancer
15.A Patient with Papillary Thyroid Carcinoma and Biochemical Evidence of Disease at Follow-Up Visits and Increasing Serum Tg Values at the Follow-Up Assessments
16.A Young Patient with Recurrent Lymph Node Involvement: Imaging, Cytology, and Thyroglobulin Washout
17.Papillary Thyroid Carcinoma Diagnosed During Pregnancy
18.Risks of Thyroid Hormone Suppression for Differentiated Thyroid Cancer in the Elderly
19.A Patient in Whom One Pathologist Says She Has Cancer, and Another Says that the Lesion Is Benign
20.A Case with Postsurgical Hypoparathyroidism
21.A Patient with Postsurgical Recurrent Laryngeal Nerve Damage and Nerve Monitoring
22.A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with Nodal Metastases Detected During Follow-Up in a Younger Patient
23.A Case of Papillary Thyroid Cancer Without Aggressive Histological Features with Nodal Metastases in an Older Patient
24.A Patient with a Large Hürthle Cell Carcinoma of the Thyroid and Nodal Metastases
25.A Case of a Large, Invasive PTC with Gross Residual Disease (pT4) After Surgery
26.A Patient with Papillary Carcinoma of the Thyroid with Elevated Serum Thyroglobulin but Negative Imaging Studies
27.A Young Child with Papillary Thyroid Cancer and Metastatic Pulmonary Disease: Role of Radioactive Iodine Therapy in Children
28.A Patient with Bone Metastases from Follicular Carcinoma of the Thyroid
29.Radioiodine Therapy in Lactating Women with Higher-Risk Differentiated Thyroid Cancer
30.A Case of a Patient with Radioactive Iodine Refractory Differentiated Thyroid Cancer with Progressive Neck Disease (Latero-cervical Lymph Nodes) and Stable, Small Lung Metastases
31.A Case of an Elderly Patient with Advanced Disease and Non-radioiodine-avid Metastases
32.RAI-Refractory Differentiated Thyroid Cancer with Multiple Organ Progressive Disease
33.RAI-Refractory Differentiated Thyroid Cancer and Lung Lesions Causing Bleeding
34.A Patient with Follicular Thyroid Cancer and a Painful Bone Metastases at Risk for Pathologic Fracture
35.Differentiated Thyroid Cancer and Brain Metastases
36.RAI-Refractory, Advanced Differentiated Thyroid Cancer Receiving Tyrosine Kinase Inhibitor Treatment: Checking for Drug-Drug Interactions
37.A Patient with Advanced Differentiated Radioactive Iodine-Refractory Thyroid Cancer Receiving Tyrosine Kinase Inhibitor Treatment: Managing Hypertension, QTc Prolongation, Dermatologic and Gastrointestinal Adverse Events
38.Management of Postoperative Hypercalcitoninemia in MTC
39.A Patient with Metastatic Medullary Thyroid Carcinoma (MTC) and Tumor-Related Diarrhea
40.Clinical Management of a Patient with a Locally Recurrent Medullary Thyroid Cancer and Asymptomatic Slowly Progressing Distant Metastases
41.A Patient with an Advanced Medullary Thyroid Cancer and Progressive, Symptomatic Distant Metastases: When to Start Systemic Therapy
42.Medical Treatment Decision-Making for Advanced, Progressive Medullary Thyroid Cancer
43.Screening Leading to Diagnosis of C-Cell Hyperplasia
44.Increased Basal Calcitonin in Nodular Goiter: Is It Micromedullary Thyroid Cancer?
45.Timing and Extent of Surgery for a Pediatric Patient with Hereditary MTC and Positive Screening for the S891A
46.Thyroid Lymphoma: Differential Diagnosis and Management
47.Anaplastic Thyroid Cancer: Surgery or Not in Locally Advanced Disease

- A cased-based, practical guide to the management of various forms of thyroid cancer and associated clinical issues
- Discusses history, diagnosis and treatment of low and high risk differentiated thyroid cancer, medullary thyroid cancer, thyroid lymphoma and anaplastic thyroid cancer
- An excellent resource for practicing clinicians, residents and students alike

Comprised exclusively of clinical cases covering the diagnosis and treatment of thyroid cancer and related clinical issues, this concise, practical casebook will provide clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various forms of thyroid cancer that they may encounter. Each chapter is a case report, written by recognized experts, that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature. Cases included illustrate treatment for both low and high risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer, thyroid lymphoma and anaplastic thyroid cancer. Pragmatic and reader-friendly, Thyroid Cancer: A CaseBased Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike.

Authors
- David S. Cooper, MD, Professor of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Cosimo Durante, MD, Department of Internal Medicine, University of Rome - Sapienza, Rome, Italy