TNM SUPPLEMENT: A COMMENTARY ON UNIFORM USE, 5TH EDITION

Preface viii
Organizations Associated with the TNM System xiii
National Committees xiii
Acknowledgements xv
Abbreviations xvi
• Chapter 1 Explanatory Notes – General
The General Rules of the TNM System 1
The TNM Clinical and Pathological Classifications 7
Residual Tumour (R) Classification 15
Additional Descriptors 20
Optional Descriptors 24
Unknown Primary 25
Staging of Tumours for Which No TNM Classification is Provided 25
Histopathological Grading 26
References 28
• Chapter 2 Explanatory Notes – Specific Anatomical Sites
Head and Neck Tumours 34
Digestive System Tumours 54
Lung, Pleural and Thymic Tumours 85
Bone Tumours 104
Soft Tissue Tumours 106
Gastrointestinal Stromal Tumour (GIST) 108
Skin Tumours 110
Breast Tumours 118
Gynaecological Tumours 122
Urological Tumours 131
Ophthalmic Tumours 142
Hodgkin and Non-Hodgkin Lymphomas 149
References 150
• Chapter 3 Site-Specific Requirements for pT and pN
Introduction 157
Head and Neck Tumours 160
Digestive System Tumours 166
Lung and Pleural Tumours 173
Tumours of Bone and Soft Tissues 176
Skin Tumours 179
Breast Tumours 183
Gynaecological Tumours 185
Urological Tumours 188
Adrenal Cortex Tumours 192
Ophthalmic Tumours 193
Hodgkin and Non-Hodgkin Lymphomas 195
References 196
• Chapter 4 New TNM Classifications Recommended for Testing and Other Classifications
Introduction 198
General 198
Specific 198
Non Upper Aerodigestive Tract Mucosal Melanoma 199
Primary Liver Carcinoma of Infants and Children/Hepatoblastoma 200
Primary Cutaneous Lymphomas 202
Cutaneous T-Cell Lymphomas 202
Primary Cutaneous Lymphomas 203
Histopathologic Staging of Lymph Nodes in Mycosis Fungoides and Sézary Syndrome 204
Primary Cutaneous B-Cell/T-Cell Lymphoma (Non-MF/SS Lymphoma) 206
Multiple Myeloma 207
Leukaemia 208
References 208
• Chapter 5 Optional Proposals for Testing New Subcategories of TNM
All Tumour Sites 210
Head and Neck Tumours 210
Digestive System Tumours 211
Lung Tumours 213
Breast Tumours (ICD-0-3 C50) 214
Gynaecological Tumours 215
Urological Tumours 215
References 216
• Chapter 6 Frequently Asked Questions
General Questions 218
Site-Specific Questions 229
References 289
Index 291
Plate section facing p. 48

The Union for International Cancer Controls (UICC) TNM classification system is the most widely used cancer classification and staging system in the world. It is used to describe the anatomical extent of disease and it is essential to patient care, research and cancer control.
This fifth edition of the TNM Supplement: A Commentary of Uniform Use offers practitioners a wealth of material intended to complement the system?s day-to-day use. The volume features:
• Updated definitions of terms used in cancer staging.
• New sections on carcinomas of the thymus, sarcomas of the spine and pelvis and soft tissue sarcomas of the head and neck, and comprehensive updates to the head and neck carcinomas, carcinomas of the lung and neuroendocrine tumours sections.
• Frequently asked questions from the UICC helpdesk.
The Supplement may be treated as a companion text to the recent eighth edition of the TNM Classification of Malignant Tumours (978-1-119-26357-9), supporting the correct and uniform application of the TNM classification system. The TNM Supplement can also be utilised as a standalone book, providing explanations and examples to answer many questions that arise during the daily use of the TNM cancer classification and staging system, particularly in unusual cases.