TRANSLATIONAL IMMUNOLOGY. MECHANISMS AND PHARMACOLOGIC APPROACHES. PRINT ON DEMAND

• Section A: Human Immunology
Chapter 1: Systems Immunology
Chapter 2: Congenital Immunodeficiency Diseases: Crossroad of Infection, Autoimmunity, and Hyperinflammation
Chapter 3: Phenome-Wide Association Study
Chapter 4: TCR Repertoire Analysis
• Section B: Emerging Pharmacological Targets
Chapter 5: Th17 Cells
Chapter 6: Th9 Cells as Targets for Immunotherapy
Chapter 7: T Follicular Helper Cells as a Therapeutic Target for Autoimmune Diseases
Chapter 8: Regulatory T Cells: Translational Immunology: Mechanisms and Pharmacologic Approaches
Chapter 9: Regulatory B Cells
• Section C: New Approaches
Chapter 10: Therapeutic Immune Tolerance Approaches for the Treatment of Allergic Disease
Chapter 11: Humanized Mice in Translational Immunology
Chapter 12: Immunological Biomarkers for Patient Stratification

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field.

KEY FEATURES
• Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies
• Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development
• Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression
• Provides information on new strategies and outstanding issues that should be addressed in future research.

Author
Seng-Lai Tan, EMD Serono Research and Development Center, Billerica, MA, USA