TRANSLATIONAL RESEARCH IN TRAUMATIC BRAIN INJURY

Translational Research in Traumatic Brain Injury is designed to address the key issues in the epidemiology, basic science, and treatment of traumatic brain injury (TBI). Edited by two clinically active physician scientists, the book presents contributions from faculty who are international leaders in the areas of molecular biology, translational modeling, treatment, and rehabilitation of traumatic brain injury.
The book covers a wide scope of TBI research critically important to the neurobiology research community, clinicians involved in the care of TBI patients, as well as industry leaders interested in developing new therapies for acute brain injury. It examines the full spectrum of TBI events, from mild sports-related injuries to severe blast injuries. It discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments. The book also describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder.

Features
- Covers the spectrum of TBI, from mild sports-related injuries to severe blast injuries
- Discusses fundamental cell mechanisms and pathophysiology, as well as animal modeling, clinical diagnosis, current therapeutic strategies, and future treatments
-Describes long-term neuropsychiatric symptoms and the relationship of TBI to the development of post-concussive syndrome and post-traumatic stress disorder
- Written by international leaders across multiple disciplines, including neurobiology, neurology, neurosurgery, intensive care medicine, psychiatry, and rehabilitative medicine.

Editor(s) Bio

Daniel Laskowitz, MD, MHS, professor of neurology, anesthesiology & neurobiology; and director, Neurovascular Laboratories, Duke University Medical Center, Durham, North Carolina, USA

Gerald A. Grant, MD, FACS, division chief, Pediatric Neurosurgery; vice chair for pediatric neurosurgery and associate program director; and associate professor, Department of Neurosurgery; Stanford University/Lucile Packard Children's Hospital, California, USA.

Table of Contents
Epidemiology

Sport-Related Traumatic Brain Injury

Diffuse Axonal Injury

Blood-Brain Barrier Pathophysiology following Traumatic Brain Injury

Cellular and Molecular Mechanisms of Secondary Neuronal Injury following Traumatic Brain Injury

Neuroinflammation

Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans

Neuroplasticity after Traumatic Brain Injury

Genetic Influences in Traumatic Brain Injury

Modeling Post-Traumatic Epilepsy for Therapy Development

Translational Principles of Neuroprotective and Neurorestorative Therapy Testing in Animal Models of Traumatic Brain Injury

Biomarkers of Traumatic Brain Injury and Their Relationship to Pathology

Advanced Neuroimaging of Mild Traumatic Brain Injury

Epilepsy after Traumatic Brain Injury

Intracranial Pressure Monitoring and Management

Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment

Traumatic Brain Injury and Potential for Neuromodulation

Enhanced Functional Outcome from Traumatic Brain Injury with Brain-Machine Interface Neuromodulation: Neuroprosthetic Scaling in Relation to Injury Severity

Neurocognitive and Psychiatric Symptoms following Mild Traumatic Brain Injury