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213,41 ۥ Part One Introduction: The Case for Concern about Mutation and Cancer Susceptibility during Critical Windows of Development and the Opportunity to Translate Toxicology into a Therapeutic Discipline 1
1 What Stressors Cause Cancer and When? 3
2 What Mutagenic Events Contribute to Human Cancer and Genetic Disease? 61
3 Developmental Origins of Cancer 111
4 The Mechanistic Basis of Cancer Prevention 147
• Part Two Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and Progression Over Time 171
5 Diet Factors in Cancer Risk 173
6 Voluntary Exposures: Natural Herbals, Supplements, and Substances of Abuse – What Evidence Distinguishes Therapeutic from Adverse Responses? 199
7 Voluntary Exposures: Pharmaceutical Chemicals in Prescription and Over-the-Counter Drugs – Passing the Testing Gauntlet 213
8 Children’s and Adult Involuntary and Occupational Exposures and Cancer 259
• Part Three Gene–Environment Interactions 317
9 Ethnicity, Geographic Location, and Cancer 319
10 Dietary/Supplemental Interventions and Personal Dietary Preferences for Cancer: Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction 363
11 Social Determinants of Health and the Environmental Exposures: A Promising Partnership 395
12 Bisphenol A and Nongenotoxic Drivers of Cancer 417
13 Toxicoepigenetics and Effects on Life Course Disease Susceptibility 439
14 Tumor-Promoting/Associated Inflammation and the Microenvironment: A State of the Science and New Horizons 473
15 Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology 511
16 Circulating Molecular and Cellular Biomarkers in Cancer 609
17 Global Profiling Platforms and Data Integration to Inform Systems Biology and Translational Toxicology 657
18 Developing a Translational Toxicology Therapeutic Portfolio for Cancer Risk Reduction 691
19 Ethical Considerations in Developing Strategies for Protecting Fetuses, Neonates, Children, and Adolescents from Exposures to Hazardous Environmental Agents 711
Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity.
• Provides information on lifestyle choices that can reduce cancer risk
• Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants
• Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health
• Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms
Authors
• MICHAEL D. WATERS, PhD, is an independent consultant with over 40 years of toxicology and toxicogenomics research experience at the EPA, at NIH/NIEHS and in the private sector. He has held adjunct professorships in toxicology and pharmacology at both the University of North Carolina and Duke University.
• CLAUDE L. HUGHES, MD, PhD, is an Executive Director in the Therapeutic Science and Strategy Unit at QuintilesIMS. He is also an Adjunct Professor at North Carolina State University, and Wake Forest University as well as a Consulting Professor at Duke University Medical Center.
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