TUMOR LIQUID BIOPSIES (SOFTCOVER)

1. Pathophysiology of Tumor Cell Release into the Circulation and Characterization of CTC
2. Circulating Tumor Cell Enrichment Technologies
3. Genetic Analysis of Circulating Tumour Cells
4. Quantitative Analysis of Circulating Tumor Cells Using RNA-Based Digital Scoring
5. Circulating Tumor Cells: High-Throughput Imaging of CTCs and Bioinformatic Analysis
6. Circulating Tumour Cells in Lung Cancer
7. Circulating Tumor Cells in Breast Cancer
8. Clinical Applications of Circulating Tumor Cells in Breast Cancer
9. Pathophysiology of ctDNA Release into the Circulation and Its Characteristics: What Is Important for Clinical Applications
10. Enrichment and Analysis of ctDNA
11. Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling
12. Review ctDNA and Breast Cancer
13. Cell-Free DNA in the Management of Colorectal Cancer
14. Dynamic Treatment Stratification Using ctDNA
15. Circulating miRNAs as Biomarker in Cancer
16. Circulating MicroRNAs as Potential Biomarkers for Lung Cancer
17. Extracellular Vesicles: Recent Developments in Technology and Perspectives for Cancer Liquid Biopsy
18. Computational Analysis of DNA and RNA Sequencing Data Obtained from Liquid Biopsies

This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Features
• Describes the cutting-edge liquid biopsy technologies that promise to revolutionize oncology practice
• Covers all basic approaches in the fields, with explanation of uses, benefits and limitations
• Focuses on translational aspects