1. Embryology, Histology, and Anatomy
2. Benign Hepatocellular Tumors and Tumor-Like Lesions
3. Hepatocellular Carcinoma
4. Fibrolamellar Carcinoma
5. Pediatric Liver Tumors
6. Benign and Borderline Biliary Neoplasms and Tumor-Like Lesions
7. Intrahepatic Cholangiocarcinoma and Precursor Lesions
8. Combined Hepatocellular-Cholangiocarcinoma
9. Mesenchymal Tumors and Tumor-Like Lesions
10. Metastatic Disease
11. Lymphoid-Hematopoietic Tumors and Tumor-Like Lesions
12. Pathologic Staging of Primary Malignant Neoplasms in Liver
Numerous advances in our understanding of the pathology and molecular features of liver tumors have been made since the publication of the previous series, nearly two decades ago. Examples of recent advances include the identification of novel entities, including their precursor lesions, the discovery of key molecular changes, including the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, and the subtyping of hepatocellular adenomas using molecular and immunohistochemical methods. Together with the more unified classification and terminology of intrahepatic bile duct tumors and their precursors, these advances call for updated information that is presented in this volume.
• Michael Torbenson, MD Professor of Pathology Mayo Cinic Rochester, Minnesota, USA.
• Yoh Zen, MD, PhD, FRCPath Professor of Pathology Department of Diagnostic Pathology Kobe University Graduate School of Medicine Kobe, Japan.
• Matthew M. Yeh, MD, PhD Professor of Pathology Adjunct Professor of Medicine Director, Gastrointestinal and Hepatic Pathology Fellowship Program University of Washington School of Medicine Seattle, Washingto, USA.