TUMORS OF THE SALIVARY GLANDS (AFIP ATLASES OF TUMOR AND NON-TUMOR PATHOLOGY, SERIES 5, VOL. 5)

1. The Normal Salivary Glands. . 1
• Development1
• Anatomy3
• Parotid Gland. 3
• Submandibular Gland7
• Sublingual Gland. 8
• Minor Salivary Glands8
• Histology8
• Parotid Gland. 8
• Submandibular Gland13
• Sublingual Gland. 15
• Minor Salivary Glands15
• Ultrastructure . . 16
• Acinar Cells. . 16
• Myoepithelial Cells. . 17
• Intercalated Duct Cells. . 18
• Striated Duct Cells18
• Immunohistochemistry 19
• Physiology. . 21
2. Classification. . 27
3. Salivary Gland Tumors: General Considerations . 31
• Etiology. 31
• Incidence/Demographic Features/Clinical Features31
• Site-Specific Tumor Differences. 32
• Intraoperative Consultation/Core Needle Biopsy. . 33
• Histologic Grading/Transformation35
• Other Prognostic Features. . 36
• Clinical Staging. 38
• Diagnostic Imaging. 42
• Immunohistochemistry 43
• Molecular Testing . . 44
4. Cytopathology of Neoplasms of the Major Salivary Glands. . 53
• Fine-Needle Aspiration Biopsy . 53
• Accuracy. . 53
• Complications55
• Classification56
• Normal Cytopathology. 58
• Cytopathology of Tumor-Like Entities. 58
• Cysts . 58
• Sialadenosis. . 60
• Cytopathology of Benign Epithelial Neoplasms60
• Pleomorphic Adenoma. . 60
• Basal Cell Adenoma. . 61
• Warthin Tumor. . 66
• Oncocytoma/Nodular Oncocytic Hyperplasia/Oncocytic Cystadenoma . . 68
• Myoepithelioma. 68
• Cytopathology of Malignant Epithelial Neoplasms69
• Mucoepidermoid Carcinoma. 69
• Acinic Cell Carcinoma . . 75
• Secretory Carcinoma. 78
• Adenoid Cystic Carcinoma. . 80
• Polymorphous Adenocarcinoma. 82
• Carcinoma Ex-Pleomorphic Adenoma. . 82
• Basal Cell Adenocarcinoma. . 84
• Adenocarcinoma, NOS and Cystadenocarcinoma84
• Hyalinizing Clear Cell Carcinoma85
• Epithelial-Myoepithelial Carcinoma. 86
• Salivary Duct Carcinoma 87
• Myoepithelial Carcinoma89
• Lymphoepithelial Carcinoma90
• Sebaceous Adenocarcinoma . 90
• Oncocytic Carcinoma91
• Cytopathology of Benign Mesenchymal Neoplasms92
• Hemangioma. 92
• Lipoma/Sialolipoma . 92
• Lymphangioma. . 93
• Nodular Fasciitis . 93
• Schwannoma. 93
• Cytopathology of Malignant Mesenchymal Neoplasms . . 95
• Malignant Peripheral Nerve Sheath Tumor. 95
• Ewing Sarcoma . . 96
• Alveolar Rhabdomyosarcoma97
• Cytopathology of Lymphoproliferative Lesions97
• Extranodal Marginal Zone Lymphoma. . 98
• Diffuse Large B-Cell Lymphoma. 98
• Cytopathology of Secondary Tumors. . 99
• Squamous Cell Carcinoma. . 99
• Neuroendocrine Carcinoma/Merkel Cell Carcinoma99
5. Benign Epithelial Neoplasms. . 109
• Pleomorphic Adenoma (Benign Mixed Tumor). 109
• Basal Cell Adenoma. 138
• Warthin Tumor. 152
• Oncocytoma 166
• Canalicular Adenoma177
• Striated Duct Adenoma. 185
• Cystadenoma189
• Myoepithelioma. 195
• Sebaceous Adenoma, Sebaceous Lymphadenoma, and Lymphadenoma. . 207
• Ductal Papillomas. . 216
• Sialadenoma Papilliferum. . 225
• Salivary Gland Anlage Tumor. . 230
• Sclerosing Polycystic Adenoma. 232
6. Malignant Epithelial Neoplasms. . 265
• Mucoepidermoid Carcinoma . . 265
• Adenocarcinoma, Not Otherwise Specified 290
• Acinic Cell Carcinoma . 303
• Secretory Carcinoma326
• Adenoid Cystic Carcinoma. 337
• Polymorphous Adenocarcinoma356
• Carcinoma Ex-Pleomorphic Adenoma. 374
• Basal Cell Adenocarcinoma. 400
• Cystadenocarcinoma414
• Primary Squamous Cell Carcinoma 422
• Large Cell Undifferentiated Carcinoma 429
• Hyalinizing Clear Cell Carcinoma . 433
• Epithelial-Myoepithelial Carcinoma445
• Intraductal Carcinoma . 461
• Salivary Duct Carcinoma475
• Neuroendocrine Carcinoma497
• Myoepithelial Carcinoma. . 505
• Lymphoepithelial Carcinoma. . 514
• Oncocytic Carcinoma521
• Carcinosarcoma. 533
• Metastasizing Mixed Tumor536
• Sebaceous Adenocarcinoma 543
• Mucinous Adenocarcinoma 552
• Sialoblastoma555
7. Mesenchymal Neoplasms . 605
• Benign Lesions. . 605
• Hemangioma. 605
• Lipoma, Sialolipoma, and Oncocytic Lipoadenoma 608
• Lymphangioma. . 610
• Inflammatory Myofibroblastic Tumor . . 611
• Nodular Fasciitis . 612
• Solitary Fibrous Tumor. . 615
• Schwannoma and Neuorofibroma619
• Ectomesenchymal Chondromyxoid Tumor. 624
• Malignant Neoplasms. . 626
• Malignant Peripheral Nerve Sheath Tumor. 627
• Rhabdomyosarcoma. 628
• Ewing Sarcoma . . 630
• Other Sarcomas. . 631
8. Hematolymphoid Neoplasms of the Major Salivary Glands. . 641
• Sjögren Syndrome. . 641
• Salivary Gland Lymphomas 642
• Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue644
• Other Non-Hodgkin Lymphomas648
• Hodgkin Lymphomas and Other Hematopoietic Neoplasms . . 649
9. Secondary Tumors of the Major Salivary Glands . 655
• Cutaneous Carcinomas. 656
• Squamous Cell Carcinoma. . 656
• Basal Cell Carcinoma 657
• Merkel Cell Carcinoma. . 657
• Sebaceous Carcinoma658
• Melanoma660
• Other Metastatic Malignancies. 662
10. Tumor-Like Conditions667
• Lymphoepithelial Sialadenitis. . 667
• Sialolithiasis and Nonspecific Chronic Sialadenitis670
• IgG4-Related Sialadenitis673
• Nodular Oncocytic Hyperplasia. 677
• Necrotizing Sialometaplasia 681
• Salivary Mucoceles and Cysts. . 684
• Mucocele. 684
• Salivary Duct Cyst687
• Lymphoepithelial Cyst. . 689
• Human Immunodeficiency Virus-Associated Salivary Gland Disease. 690
• Polycystic Dysgenetic Disease. . 694
• Sialadenosis. 697
• Adenomatoid Hyperplasia. . 698
• Intercalated Duct Lesions (Hyperplasia and Adenoma)700
Index. 713

This book serves as a one-stop, comprehensive reference for the pathology of salivary gland neoplasms, with an emphasis on numerous high-quality, illustrative photomicrographs. The authors incorporated the most cutting-edge genetic data emerging on such tumors, as this information often has a profound impact on their diagnosis and classification. With the quickly evolving nature of salivary gland pathology, this contribution to the Fifth Series is a key update to the previous edition from the Fourth Series, which was published in 2008.