UICC MANUAL OF CLINICAL ONCOLOGY

PART 1 General principles of cancer diagnosis and management 1
Principles of knowledge generation and translation
1 – Cancer epidemiology 3
2 – Levels of evidence, guidelines and standards 12
3 – Prognosis and classification of cancer 23
4 – Principles of cancer staging 34
5 – Assessment of treatment outcome 40
6 – Cancer informatics 53
Principles of cancer diagnosis
7 – Imaging 63
8 – Pathology 83
Principles of treatment
9 – Principles of surgery 98
10 – Principles of radiotherapy 108
11 – Principles of systemic therapy 124
Special settings, supportive care and survivorship
12 – Treatment in pregnancy 134
13 – Treatment in the elderly 139
14 – Oncology emergencies 145
15 – Supportive care during curative treatment 155
16 – Pain management in cancer 168
17 – Palliative care 174
18 – Survivorship 184
19 – Rehabilitation 194
PART 2 Site-specific multidisciplinary cancer management 203
Thoracic malignancies
20 – Lung 205
Breast
21 – Breast 221
Gastrointestinal malignancies
22 – Liver 241
23 – Biliary tract and pancreas 263
23.1 – Biliary tract 263
23.2 – Pancreas 270
24 – Oesophagus 280
25 – Stomach 297
26 – Colon, rectum and anus 308
26.1 – Colon and rectum 308
26.2 – Anus 327
Genitourinary malignancies
27 – Prostate 333
28 – Bladder and other urothelium 343
29 – Kidney 354
30 – Testicular germ cell tumours 368
31 – Penis 384
Haematological malignancies
32 – Lymphoma 392
33 – Myeloma 415
34 – Leukaemia 427
Gynaecological cancers
35 – Cervix 449
36 – Uterus 467
37 – Ovary and fallopian tube 479
Head and neck cancer
39 – General principles of head and neck cancer management 503
40 – Nasopharynx 512
41 – Oral cavity 524
42 – Larynx and hypopharynx 542
43 – Oropharynx 559
44 – Major salivary glands 571
45 – Nasal cavity and paranasal sinus 586
46 – Head and neck unknown primary 597
Endocrine tumors
47 – Pituitary 609
48 – Thyroid 626
49 – Adrenal tumours 641
50 – Neuroendocrine tumours 656
Dermatological cancer
51 – Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma 674
52 – Melanoma 689
Central nervous system and ocular cancers
53 – Central nervous system 706
54 – Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymph
Sarcoma
55 – Bone (osteosarcoma) 745
56 – Soft tissue 754
Childhood malignancies
57 – Paediatric tumors 768
Specific cancer situations
58 – Cancer of unknown primary (no 59 – HIV and transplant-related neoplasms 797
59.1 – HIV-related neoplasms 797
59.2 – Post-transplantation lymphoproliferative disease 809
59.3 – Cancer following solid organ transplantation 812
Index 815

The Manual of Clinical Oncology, Ninth Edition, published with the International Union Against Cancer (UICC), provides a concise, accessible and feasible reference covering state of art multidisciplinary clinical oncology in order to meet the needs of clinicians caring for cancer patients throughout the world.
Edited by world-renowned practising oncologists and written by key opinion leaders, this book contains authoritative and up-to-date information on cancer detection, diagnosis and treatment alongside topics such as survivorship, special populations and palliative care.
Remodelled and revised for the ninth edition to provide practical information to oncology workers, the UICC Manual of Clinical Oncology is structured in two parts. Part 1 covers general principles of cancer diagnosis and management with additional attention to special settings in oncology, including supportive care and survivorship, and Part 2 covers site-specific multidisciplinary cancer management. The edition includes up-to-date summaries of all treatment modalities (medical, surgical and radiation) for all tumour sites. It also contains the latest TNM classifications outlined in the TNM Classification of Malignant Tumours.
The ninth edition includes:
Practical presentation with bullet points, tables, and flow charts intended to facilitate quick reference for day-to-day clinical practice in busy oncology environments,
Representation of multidisciplinary care for site specific management,
Evidence-based approaches to management, including specific treatment recommendations and investigations guided by clinical practice guidelines,
State of art evidence-based recommendations that take into consideration the lack of availability of certain medications or resources, as well as practice variations, in different and remote regions of the world, and
Contemporary topics on cancer treatment, such as cancer informatics, evidence levels, principles of prognostication, survivorship and cancer in pregnancy.
Oncologists, oncologists-in-training, nurses working with cancer patients and other health professionals responsible for treating and caring for those with cancers will find the UICC Manual of Clinical Oncology an indispensable and comprehensive resource.

Authors
Brian O’Sullivan, MD, FRCPC, FRCPI, FFRRCSI (Hon), FASTRO (Editor-in-Chief)
Professor, Department of Radiation Oncology
Bartley-Smith / Wharton Chair in Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto
Toronto, Ontario, Canada
James D Brierley, BSc, MB, FRCP, FRCR, FRCPC (Associate Editor)
Professor, Department of Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto
Toronto, Ontario, Canada
Anil K. D’Cruz MS, DNB, FRCS (Associate Editor)
Professor, Department of Head and Neck Surgical Oncology
Tata Memorial Hospital, Mumbai, India
Martin F. Fey, MD (Associate Editor)
Professor, Department of Medical Oncology
Inselspital and University Hospital
Bern, Switzerland
Raphael Pollock, MD, PhD (Associate Editor)
Director of Surgical Oncology, Chief of Surgical Services
The James NCICCC/Ohio State University
Columbus, OH, USA
Jan B. Vermorken, MD, PhD (Associate Editor)
Emeritus Professor of Oncology
Faculty of Medicine and Health Sciences,
University of Antwerp, Antwerp, Belgium
Department of Medical Oncology
Antwerp University Hospital
Edegem, Belgium
Shao Hui Huang, MD, MSc, MRT(T) (Editorial coordinator)
Assistant Professor
Department of Radiation Oncology
Princess Margaret Cancer Centre / University of Toronto