UNDERSTANDING DEPRESSION, VOLUME 1: BIOMEDICAL AND NEUROBIOLOGICAL BACKGROUND

1. Highlights on Pharmacogenetics and Pharmacogenomics in Depression
2. Imaging Genetics Studies on Susceptibility Genes for Major Depressive Disorder, the Present and the Future
3. Gene-Environment Interactions and Role of Epigenetics in Depression
4. miRNAs As Critical Epigenetic Players in Determining Neurobiological Correlates of Major Depressive Disorder
5. The Role of Early Life Stress in HPA Axis and Depression
6. Complex Role of the Serotonin Receptors in Depression: Implications for Treatment
7. Emerging Role of Glutamate Receptors in Pathophysiology of Depression
8. New Perspective on mTOR Pathways: A New Target of Depression
9. Biological Markers to Differentiate the Subtypes of Depression
10. Structural, Functional, and Molecular Neuroimaging in Depression
11. Why Do We Need Psychopathology? From the Brain’s Resting State to “Spatiotemporal Psychopathology” of Depression
12. Neuroimaging in Depression: A Tool Toward Individualized Prediction of Treatment Outcome
13. Cortical–Subcortical Interactions in the Pathophysiology of Depression
14. Pathophysiology and Treatment Strategies for Different Types of Depression
15. The Effect of Neurostimulation in Depression
16. Chronic Inflammation and Resulting Neuroprogression in Major Depression
17. Gut-Microbiota-Brain Axis and Depression
18. Modulating Microglial Activation As a Possible Therapeutic Target for Depression
19. Experimental Animal Models for Depressive Disorders: Relevance to Drug Discovery
20. The Use of Animal Models in Defining Antidepressant Response: A Translational Approach
21. Precision Psychiatry: Personalized Clinical Approach to Depression
22. Risk Factors and Prevention Strategies for Depression in Childhood and Adolescence
23. Neurobiology and Risk Factors of Late-Life Depression
24. Gender Differences in Depression
25. An Update on the Epidemiology of Major Depressive Disorder Across Cultures

This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression and their relation to clinical manifestations and the development of more effective treatments. This first volume is devoted specifically to biomedical and neurobiological issues. Detailed information is presented on a wide range of topics, including genetics, molecular and cellular biology, and aspects at the neural circuit and multicellular system levels. Readers will gain a deeper appreciation of the factors and interactions underlying individual variation in responsiveness to stress and vulnerability to depression, as well as a clear understanding of potential treatment targets and causes of treatment resistance based on the latest research. A concluding section considers progress towards precision psychiatry and gender and cultural differences in depression. The companion volume is dedicated to clinical and management issues in depression. Understanding Depression will be an excellent source of information for both researchers and practitioners in the field.

Features
• Equips readers with an up-to-date understanding of the biomedical and neurobiological underpinnings of depression
• Elucidates the factors and interactions underlying individual variation in vulnerability to depression
• Identifies potential treatment targets and causes of treatment resistance