VITAMIN E IN HUMAN HEALTH (NUTRITION AND HEALTH)

1. Introduction: Why (Another) Book on Vitamin E?
2. History of Vitamin E Research
3. Antioxidative Activity of Vitamin E
4. Bioavailability and Metabolism of Vitamin E
5. Occurrence and Bioactivities of Minor Vitamin E Derivatives
6. Bioactivity of Vitamin E Long-Chain Metabolites
7. Gene Regulatory Activity of Vitamin E
8. Metabolomic Approaches in Vitamin E Research
9. The Tocopherol Transfer Protein: Regulator of Vitamin E Status
10. The Role of Lipid Rafts in Mediating the Anticancer Effects of ?-Tocotrienol
11. Interaction Between Vitamin E and Polyunsaturated Fatty Acids
12. The Challenge of Defining Daily Intake Recommendations: Vitamin E and Polyunsaturated Fatty Acids
13. Vitamin E Intake and Serum Levels in the General Population: A Global Perspective
14. Vitamin E Intakes and Status in Toddlers, School Kids and Adolescents: What Do We Know?
15. Vitamin E Serum Levels and the Challenge to Correct for Lipids: Accounting for the Usual Double Correction for Variance Shared by Total Cholesterol and Fasting Triglycerides Reveals New Insights into the Association with the One-Carbon Pathway
16. Stability of Vitamin E in Foods
17. Vitamin E and Mortality: A Critical Perspective of the Conflicting Meta-analysis Outcomes
18. Vitamin E-Drug Interactions
19. Vitamin E: Interactions with Vitamin K and Other Bioactive Compounds
20. Clinical Cardiovascular Disease Trials: The Vitamin E Case
21. Haptoglobin Genotype and a Promising Pharmacogenomic Approach to Prevent Diabetic Atherothrombosis with Vitamin E Supplementation
22. Vitamin E and Metabolic Syndrome
23. Vitamin E in Nonalcoholic Fatty Liver Disease
24. The Role of Vitamin E in Aging and Alzheimer’s Disease
25. The Impact of Vitamin E Isoforms on Asthma and Allergy
26. Vitamin E, Immune Function, and Protection Against Infection
27. Vitamin E and Air Pollution
28. The Role of Vitamin E in Pregnancy
29. Vitamin E and Healthcare Costs: Models to Assess the Impact
30. Do Consumers Care About Micronutrients? A Perspective on the Possible Role of Vitamin E in the Dietary Choices of Consumers
31. Addressing Key Knowledge Gaps in Nutrition Research and the Impact of Funding Priorities in Human Nutrition

Vitamin E is a well described and established fat-soluble essential micronutrient and as such has to be provided to the human body on a regular basis in order to avoid deficiency and maintain a healthy status. This is well established and also reviewed in a number of publications. However, a huge body of evidence has accumulated over the last decade, or so, which provides new insights on the mode of action of vitamin E, and the biological role of the tocopherol isomers, and sheds new light on the role of vitamin E in human health. Both fundamental knowledge gain and new data on the role and challenges of vitamin E as an essential micronutrient, including emerging evidence on clinical benefits, will be addressed to put this essential micronutrient in the appropriate perspective.
Given this level of new evidence which has emerged over the recent years, a book on vitamin E will put into perspective the concerns which have been raised on vitamin E and which resulted in a misinformation and confusion of the public regarding the importance of vitamin E for human health. This book will reemphasize that Vitamin E is clearly required for human health and its inadequacy leads to increased risk of a variety of diseases. In addition new data of non-communicable diseases (NCD) dependent on vitamin E status show that a lifetime of low intake increases risks of development, severity and complications of NCDs. This text will put the vitamin E case into an up-to-date, science based, applicable real-life perspective and offer pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. The purpose of this book is also to raise awareness not only in the nutrition and medical community, but also in the public media that there are a number of health conditions where an increased intake of vitamin E can be of potential importance. Further this review should also stimulate funding organizations and agencies to increase their support for vitamin E research in order to facilitate the further exploration of the safe and efficacious use of this essential micronutrient.

Features
• The start of each chapter presents a summary of key chapter points One of few professional texts focusing exclusively on vitamin E Written by distinguished experts in their respective fields

Authors
• Peter WeberInstitute of Biological Chemistry and NutritionUniversity of HohenheimStuttgart, Germany
• Marc BirringerDepartment of Nutritional, Food and Consumer SciencesFulda University of Applied SciencesFulda, Germany
• Jeffrey B. Blumberg,PhD, Jean Mayer USDA Human Nutrition Research Center on AgingFriedman School of Nutrition Science and PolicyTufts University
• Manfred Eggersdorfer DSM Nutritional ProductsKaiseraugst, Switzerland
• Jan FrankInstitute of Biological Chemistry and NutritionUniversity of HohenheimStuttgart, Germany