VITILIGO: MEDICAL AND SURGICAL MANAGMEMENT

• Section 1 Basic Science 1
1 Introduction 3
2 Melanocyte and Melanogenesis: Applied Anatomy and Physiology 9
3 Epidemiology of Vitiligo 15
4 Pathogenesis of Vitiligo 19
5 Understanding the Mechanisms of Repigmentation in Vitiligo 27
• Section 2 Clinical Science 33
6 Classification and Clinical Features of Vitiligo 35
7 Outcome Measures for Vitiligo 49
8 Evaluation and Treatment of the Psychosocial Burden of Vitiligo 61
9 Patient Support, Education, and Compliance 69
10 Goals of Vitiligo Treatment, and Evidence-Based Practice Guidelines for Medical and Surgical Management 77
11 The Concept of Stability of Vitiligo and Stabilization Therapies 81
• Section 3 Phototherapy 91
12 Narrow-Band Ultraviolet B Phototherapy in Vitiligo 93
13 UVA-Based Phototherapy: PUVA, PUVA-Sol, and UVA1 Phototherapy 105
14 Targeted Phototherapy in Vitiligo 113
• Section 4 Medical Management 123
15 Immunomodulators and Immunosuppressives in Vitiligo Treatment 125
16 Topical Glucocorticoids, Topical Calcineurin Inhibitors, and Topical Vitamin D3 Analogs 133
17 Other Therapies in Vitiligo 141
18 Biologic Therapies for Vitiligo 151
19 Evidence Toward Integrated Management of Vitiligo, Combining Ayurveda and Homeopathy with Modern Dermatology 159
• Section 5 Surgical Therapies: History, Patient Selection, and Classification 171
20 History and Chronology of Development of Surgical Therapies for Vitiligo 173
21 Patient Selection, Pre- and Postoperative Information in Surgical Therapies for Vitiligo 185
22 Classification of Surgical Therapies in Vitiligo 193
• Section 6 Surgical Therapies: Tissue Grafting 209
23 Minigrafting for Vitiligo 211
24 Suction Blister Epidermal Grafting 225
25 Thin and Ultra-Thin Skin Grafts for Vitiligo 241
26 Treatment of Leukoderma by Transplantation of Ultra-Thin Epidermal Sheets Using a Motorized Dermatome 249
27 Mesh Grafts for Vitiligo 257
28 Smash Grafting 261
29 Therapeutic Needling and Needling Micrografting 267
30 Complications and Limitations of Melanocyte Transplantation 273
• Section 7 Surgical Therapies: Cellular Grafting 279
31 Treatment of Leukoderma by Transplantation of Basal Cell Layer Suspension 281
32 Non-Cultured Extracted Follicle Outer Root Sheath Cell Suspension Transplantation 293
33 Long-Term Results of Non-Cultured Epidermal Cellular Grafting in Vitiligo 299
34 Simplified Non-Cultured Cellular Grafting 303
35 Novel Methods of Preparing Epidermal Cell Suspension for Transplantation in Vitiligo 309
36 Management of Vitiligo: Setting Up a Tissue Culture Laboratory 317
37 Treatment of Leukoderma by Transplantation of Cultured Autologous Melanocytes 323
38 Transplantation of In-Vitro-Cultured Epithelial Grafts for Vitiligo and Piebaldism 337
39 Application of Lasers for Abrasion in Transplantation Procedures for Vitiligo 351
40 Cell Delivery on Recipient Skin 357
41 Safety Concerns in Transplantation of In-Vitro-Cultured Cellular Grafts 363
• Section 8 Special Issues in Medical and Surgical Therapies 369
42 Surgical Management of Vitiligo of Lips, Eyelids, and Genitals 371
43 Surgical Management of Acral Vitiligo 389
44 Surgical Management of Leukotrichia 401
45 Surgical Treatments of Leukodermas Other Than Vitiligo Vulgaris 407
46 Ethnic Issues in Management of Vitiligo and Sun Protection 417
47 Management Issues for Vitiligo in Children and Pregnant Women 427
48 Combination Treatments for Vitiligo 439
49 Micropigmentation 451
50 Camouflage in Vitiligo 459
51 Depigmentation Treatment for Vitiligo: Bleaching Cream, Laser, and Cryotherapy 469
52 Future Directions in the Treatment of Vitiligo 475
53 Informed Consent 491
Index 495

Practical guidance based on expert experience and evidence for developing management strategies for vitiligo
This complete guide to vitiligo provides a full appraisal of strategy for the treatment of this autoimmune disease that affects 1-2% of the world’s population. It addresses all aspects of vitiligo, covering the science, medical and surgical therapies, and the psychological evaluations and approaches based on the proper understanding of the causes and classification of a particular case.
Management of vitiligo is challenging and requires a multipronged approach. Vitiligo: Medical and Surgical Management is a comprehensive, timely, state-of-the-art resource that will help those involved with affected patients better understand and treat this disease, which takes its toll on the mental wellness of those afflicted by it. It takes an evidenced-based approach to the disease’s treatment; provides an overview of the surgical management; covers tissue and cellular grafting; and more.
• Thoroughly guides those involved in the clinical aspects of vitiligo
• Aids diagnosis and classification of severity
• Balances evidence and experience
• Compiled by world-leading expert editors

Comprehensive in nature, Vitiligo: Medical and Surgical Management contains a strong practical element, and is a welcome go-to source for practicing dermatologists and those training to become a dermatologist.

Authors
• Somesh Gupta, MD, DNB, MNAMS, Professor, Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India
• Mats J. Olsson, MD, PhD, CEO, ParkCell AB and President, International Vitiligo Center, Uppsala, Sweden
• Davinder Parsad, MD, Professor, Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
• Henry W. Lim, MD, Chair Emeritus, Department of Dermatology and Senior Vice President for Academic Affairs, Henry Ford Health System. Past President, American Academy of Dermatology, Detroit, USA
• Nanja van Geel, MD, PhD, Professor, Department of Dermatology, Ghent University Hospital, Ghent, Belgium
• Amit G. Pandya, MD, Professor, Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas, USA