WHO CLASSIFICATION OF TUMOURS OF ENDOCRINE ORGANS. 4TH EDITION, VOLUME 10

• 1 Tumours of the pituitary gland 11
WHO classifi cation of tumours of the pituitary 12
Introduction 13
Pituitary adenoma 14
Somatotroph adenoma 19
Lactotroph adenoma 24
Thyrotroph adenoma 28
Corticotroph adenoma 30
Gonadotroph adenoma 34
Null cell adenoma 37
Plurihormonal and double adenomas 39
Pituitary carcinoma 41
Pituitary blastoma 45
Craniopharyngioma 46
Neuronal and paraneuronal tumours 48
Gangliocytoma and mixed gangliocytoma–adenoma 48
Neurocytoma 49
Paraganglioma 50
Neuroblastoma 51
Tumours of the posterior pituitary 52
Mesenchymal and stromal tumours 55
Meningioma 55
Schwannoma 56
Chordoma 57
Haemangiopericytoma / Solitary fi brous tumour 58
Haematolymphoid tumours 60
Germ cell tumours 61
Secondary tumours 63
• 2 Tumours of the thyroid gland 65
WHO classifi cation of tumours of the thyroid gland 66
TNM classifi cation of tumours of the thyroid gland 67
Introduction 68
Follicular adenoma 69
Hyalinizing trabecular tumour 73
Other encapsulated follicular-patterned thyroid tumours 75
Tumours of uncertain malignant potential 76
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features 78
Papillary thyroid carcinoma 81
Follicular thyroid carcinoma 92
Hürthle (oncocytic) cell tumours 96
Poorly differentiated thyroid carcinoma 100
Anaplastic thyroid carcinoma 104
Squamous cell carcinoma 107
Medullary thyroid carcinoma 108
Mixed medullary and follicular thyroid carcinoma 114
Mucoepidermoid carcinoma 117
Sclerosing mucoepidermoid carcinoma with eosinophilia 119
Mucinous carcinoma 121
Ectopic thymoma 122
Spindle epithelial tumour with thymus-like differentiation 123
Intrathyroid thymic carcinoma 125
Paraganglioma and mesenchymal / stromal tumours 127
Paraganglioma 127
Peripheral nerve sheath tumours 128
Benign vascular tumours 129
Angiosarcoma 129
Smooth muscle tumours 132
Solitary fi brous tumour 133
Haematolymphoid tumours 135
Langerhans cell histiocytosis 135
Rosai–Dorfman disease 136
Follicular dendritic cell sarcoma 136
Primary thyroid lymphoma 137
Germ cell tumours 139
Secondary tumours 142
• 3 Tumours of the parathyroid glands 145
WHO classifi cation of tumours of the parathyroid glands 146
TNM staging of tumours of the parathyroid glands 146
Parathyroid carcinoma 147
Parathyroid adenoma 153
Secondary, mesenchymal and other tumours 159
• 4 Tumours of the adrenal cortex 161
WHO classifi cation of tumours of the adrenal cortex 162
TNM classifi cation of tumours of the adrenal cortex 162
Adrenal cortical carcinoma 163
Adrenal cortical adenoma 169
Sex cord–stromal tumours 173
Adenomatoid tumour 174
Mesenchymal and stromal tumours 175
Myelolipoma 175
Schwannoma 176
Haematolymphoid tumours 177
Secondary tumours 178
• 5 Tumours of the adrenal medulla and extra-adrenal paraganglia 179
WHO classifi cation of tumours of the adrenal medulla and extra-adrenal paraganglia 180
TNM staging of tumours of the adrenal medulla and extra-adrenal paraganglia 180
Introduction 181
Phaeochromocytoma 183
Extra-adrenal paragangliomas 190
Head and neck paragangliomas 190
Sympathetic paraganglioma 192
Neuroblastic tumours of the adrenal gland 196
Composite phaeochromocytoma 204
Composite paraganglioma 206
• 6 Neoplasms of the neuroendocrine pancreas 209
WHO classifi cation of neoplasms of the neuroendocrine pancreas 210
TNM classifi cation of tumours of neuroendocrine pancreas 210
Introduction 211
Non-functioning (non-syndromic) neuroendocrine tumours 215
Insulinoma 222
Glucagonoma 225
Somatostatinoma 227
Gastrinoma 229
VIPoma 231
Serotonin-producing tumours with and without carcinoid syndrome 233
ACTH-producing tumour with Cushing syndrome 234
Pancreatic neuroendocrine carcinoma (poorly differentiated neuroendocrine neoplasm) 235
Mixed neuroendocrine–non-neuroendocrine neoplasms 238
Mixed ductal–neuroendocrine carcinomas 238
Mixed acinar–neuroendocrine carcinomas 239
• 7 Inherited tumour syndromes 241
Introduction 242
Multiple endocrine neoplasia type 1 243
Multiple endocrine neoplasia type 2 248
Multiple endocrine neoplasia type 4 253
Hyperparathyroidism–jaw tumour syndrome 255
Von Hippel–Lindau syndrome 257
Familial paraganglioma–phaeochromocytoma syndromes caused by SDHB, SDHC, and SDHD mutations 262
Neurofi bromatosis type 1 266
Carney complex 269
McCune–Albright syndrome 272
Familial non-medullary thyroid cancer 275
Cowden syndrome and PTEN-related lesions 275
Familial adenomatous polyposis and APC-related lesions 276
Non-syndromic familial thyroid cancer 277
Werner syndrome and Carney complex 278
DICER1 syndrome 280
Glucagon cell hyperplasia and neoplasia 282
Contributors 285
Declaration of interests 295
IARC/WHO Committee for the ICD-O 296
Sources of fi gures 297
Sources of tables 300
References 301
Subject index 347
List of abbreviations 355

The WHO Classification of Tumours of Endocrine Organs is the tenth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome.

Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, pathology, genetics, prognosis and predictive factors.

The book, prepared by 166 authors from 25 countries, contains more than 700 colour images and tables, and more than 3100 references.