WINTROBE'S CLINICAL HEMATOLOGY (2 VOLUME SET). 15TH EDITION

VOLUME 1
• Part 1 LABORA T OR Y HEMA T OL OGY
Chapter 1 Examination of the Blood and Bone Marrow 1
Chapter 2 Clinical Flow Cytometry 18
Chapter 3 Cytogenetics 48
Chapter 4 Molecular Diagnosis in Hematology 61
? SECTION 1 HEMA T OPOIESIS 69
Chapter 5 Origin and Development of Blood Cells 69
? SECTION 2 THE ER YTHROCYTE 93
Chapter 6 The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, the Mature Red Blood Cell, and Cell Destruction 93
? SECTION 3 GRANUL OCYTES AND MONOCYTES 136
Chapter 7 Neutrophilic Leukocytes 136
Chapter 8 The Human Eosinophil 168
Chapter 9 Mast Cells and Basophils: Ontogeny, Characteristics, and Functional Diversity 196
Chapter 10 Monocytes, Macrophages, and Dendritic Cells 208
? SECTION 4 THE L YMPHOCYTES 233
Chapter 11 Lymphocytes and Lymphatic Organs 233
• Part 2 THE NORMAL HEMA T OL OGIC SY STEM
Chapter 12 B Lymphocytes 267
Chapter 13 T Lymphocytes 288
Chapter 14 Natural Killer and Innate Lymphoid Cells 309
Chapter 15 Major Histocompatibility Complex 322
Chapter 16 Complement System 338
? SECTION 5 HEMOSTASIS 356
Chapter 17 Megakaryocytes 356
Chapter 18 Platelet Structure 391
Chapter 19 Platelet Function in Hemostasis and Thrombosis 402
Chapter 20 Blood Coagulation and Fibrinolysis 427
Chapter 21 Endothelium: Angiogenesis and the Regulation of Hemostasis 531
• Part 3 TRANSFUSION MEDICINE
Chapter 22 Red Cell, Platelet, and White Cell Antigens 540
Chapter 23 Transfusion Medicine 558
• Part 4 DISORDERS OF RED BLOOD CELLS
? SECTION 1 INTRODUCTION 600
Chapter 24 Anemia: General Considerations 600
? SECTION 2 DISORDERS OF IRON METABOLISM 628
Chapter 25 Iron Deficiency and Related Disorders 628
Chapter 26 Sideroblastic Anemias 656
Chapter 27 Hemochromatosis 678
Chapter 28 Porphyrias 702
? SECTION 3 HEMOLYTIC ANEMIA 726
Chapter 29 Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated With Abnormalities of the Erythrocyte Membrane 726
Chapter 30 Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders 749
Chapter 31 Autoimmune Hemolytic Anemia 770
Chapter 32 Paroxysmal Nocturnal Hemoglobinuria 792
Chapter 33 Acquired Nonimmune Hemolytic Disorders 821
? SECTION 4 HEREDITARY DISORDERS OF HEMOGLOBIN STRUCTURE AND SYNTHESIS 833
Chapter 34 Sickle Cell Anemia and Other Sickling Syndromes 833
Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin Chain Synthesis 883
Chapter 36 Hemoglobins With Altered Oxygen Affinity, Unstable Hemoglobins, M- Hemoglobins, and Dyshemoglobinemias 933
? SECTION 5 OTHER RED CELL DISORDERS 945
Chapter 37 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis 945
Chapter 38 Inherited Aplastic Anemia Syndromes Germline 974
Chapter 39 Acquired Aplastic Anemia 995
Chapter 40 Red Cell Aplasia: Acquired and Congenital Disorders 1008
Chapter 41 Congenital Dyserythropoietic Anemias 1020
Chapter 42 Anemia of Inflammation and of Systemic Disorders 1033
Chapter 43 Anemias During Pregnancy and the Postpartum Period 1047
Chapter 44 Anemias Unique to the Fetus and Neonate 1053
Chapter 45 Erythrocytosis 1070
? SECTION 1 INTRODUCTION 1080
Chapter 46 Diagnostic Approach to the Bleeding Disorders 1080
? SECTION 2 THROMBOCYTOPENIA 1095
Chapter 47 Thrombocytopenia: Pathophysiology and Classification 1095
Chapter 48 Thrombocytopenia Caused by Immunologic Platelet Destruction 1097
Chapter 49 Thrombotic Thrombocytopenic Purpura, Hemolytic- Uremic Syndrome, and Related Disorders 1123
Chapter 50 Miscellaneous Causes of Thrombocytopenia 1153
Chapter 51 Bleeding Disorders Caused by Vascular Abnormalities 1162
Chapter 52 Thrombocytosis and Essential Thrombocythemia 1175
Chapter 53 Qualitative Disorders of Platelet Function 1182
? SECTION 3 COAGULATION DISORDERS 1202
Chapter 54 Inherited Coagulation Disorders 1202
Chapter 55 Acquired Coagulation Disorders 1241
? SECTION 4 THROMBOSIS 1276
Chapter 56 Thrombosis and Antithrombotic Therapy 1276
• Part 5 DISORDERS OF HEMOSTASIS AND COAGULATION
• Part 6 DISORDERS OF LEUKOCYTES, IMMUNODEFICIENCY, AND THE SPLEEN
Chapter 57 Diagnostic Approach to Tissue Examination and Testing 1321
Chapter 58 Neutropenia 1331
Chapter 59 Qualitative Disorders of Leukocytes 1344
Chapter 60 Lysosomal Abnormalities of the Monocyte- Macrophage System: Gaucher and Niemann- Pick Diseases 1359
Chapter 61 Langerhans Cell Histiocytosis 1364

VOLUME 2

Chapter 62 Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations 1376
Chapter 63 Infectious Mononucleosis and Other Epstein- Barr Virus–Related Disorders 1382
Chapter 64 Primary Immunodeficiency Diseases 1393
Chapter 65 Human Immunodeficiency Virus Infection 1409
Chapter 66 Disorders of the Spleen 1423
Chapter 67 Tumors of the Spleen 1437
• Part 7 HEMATOLOGIC MALIGNANCIES
? SECTION 1 GENERAL ASPECTS 1444
Chapter 68 Hematopoietic Neoplasms: Principles of Pathologic Diagnosis 1444
Chapter 69 Principles of Targeted Therapies for Hematologic Malignancies 1454
Chapter 70 Infectious Complications in Hematologic Malignancies 1468
Chapter 71 Immunotherapy 1494
Chapter 72 Gene Therapy for Hematopoietic Stem Cell Disorders 1522
? SECTION 2 THE ACUTE LEUKEMIAS 1562
Chapter 73 Molecular Genetics of Acute Leukemia 1562
Chapter 74 Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes 1595
Chapter 75 Acute Lymphoblastic Leukemia in Adults 1608
Chapter 76 Acute Myeloid Leukemia in Adults 1627
Chapter 77 Acute Lymphoblastic Leukemia in Children 1667
Chapter 78 Acute Myeloid Leukemia in Children 1694
Chapter 79 Acute Promyelocytic Leukemia 1721
Chapter 80 Myelodysplastic Syndromes 1737
Chapter 81 Clonal Hematopoiesis of Indeterminate Potential and Myeloid Diseases 1754
? SECTION 3 MYELOPROLIFERATIVE DISORDERS 1763
Chapter 82 Pathology of the Myeloproliferative Neoplasms 1763
Chapter 83 Chronic Myeloid Leukemia 1782
Chapter 84 Polycythemia Vera 1808
Chapter 85 Myelofibrosis 1821
Chapter 86 Eosinophilic Neoplasms and Hypereosinophilic Syndrome 1836
Chapter 87 Systemic Mastocytosis 1849
? SECTION 4 LYMPHOPROLIFERATIVE DISORDERS 1866
Chapter 88 Diagnosis and Classification of Lymphomas 1866
Chapter 89 Molecular Genetic Aspects of Non- Hodgkin Lymphomas 1900
Chapter 90 Non- Hodgkin Lymphoma in Adults 1942
Chapter 91 Non- Hodgkin Lymphoma in Children 1991
Chapter 92 Chronic Lymphocytic Leukemia 2010
Chapter 93 Hairy Cell Leukemia 2049
Chapter 94 Cutaneous T- Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome 2072
Chapter 95 Hodgkin Lymphoma in Adults 2116
Chapter 96 Hodgkin Lymphoma in Children 2133
? SECTION 5 PLASMA CELL DYSCRASIAS 2144
Chapter 97 Practical Approach to the Evaluation of Monoclonal Gammopathies 2144
Chapter 98 Molecular Genetic Aspects of Plasma Cell Disorders 2152
Chapter 99 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma 2160
Chapter 100 Multiple Myeloma 2175
Chapter 101 Immunoglobulin Light Chain Amyloidosis 2238
Chapter 102 Waldenström Macroglobulinemia 2267
Chapter 103 Monoclonal Gammopathies of Clinical Significance 2276
• Part 8 HEMATOPOIETIC CELLULAR THERAPY
Chapter 104 Hematopoietic Cell Transplantation 2297
Chapter 105 Hematopoietic Cell Transplantation for Nonmalignant Disorders 2314
Chapter 106 Hematopoietic Cell Transplantation for Hematologic Malignancies 2335
Chapter 107 Gr aft- vs- Host Disease and Gr aft- vs- T umor Response 2355
Chapter 108 Late Effects After Hematopoietic Cell Transplantation 2371
Index I-1

Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
• Provides expert coverage of new topics, including COVID-19, palliative care and survivorship, transitioning from pediatric to adult care, and ethical issues in hematology such as management of individuals with religious/cultural objections to transfusion
• Integrates WHO classifications of hematologic neoplasms and the latest knowledge in genetics and genomics, and includes focused chapters on hematopoietic cell transplantation, gene therapy, and immunotherapy
• Emphasizes four components of diagnosis: the morphology of the peripheral smear, bone marrow, lymph nodes, and other tissues; flow cytometry; cytogenetics; and molecular markers and mutations
• Offers fresh perspectives from new section editors Drs. John Leonard (Lymphoma) and Laura Michaelis (Leukemia/MPN), as well as numerous new contributing authors, many of whom provide international viewpoints on hematology

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