BIOMARKERS OF THE TUMOR MICROENVIRONMENT. 2ND EDITION

• Part I Basic Studies: Tumor Mechanisms and Tissue Biomarkers
1 The Role of the Tumor Microenvironment in Regulating Angiogenesis 3
2 Tissue-Based Biomarkers of Tumor-Vascular Interactions 17
3 Molecular Phenotypes of Endothelial Cells in Malignant Tumors . 31
4 Lymphatics in Malignant Tumors . 53
5 Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support? 63
6 Tissue Architecture in Cancer Initiation and Progression . 91
7 Tumor-Fibroblast Interactions in Carcinomas 109
8 Stromal PDGF Receptors; Impact on Prognosis and Response to Treatment 125
9 Inflammation and Cancer: Lipid Autacoid and Cytokine Biomarkers of the Tumor Microenvironment . 139
10 Role of Lymphocytes in Cancer Immunity and Immune Evasion Mechanisms 159
11 Drivers of EMT and Immune Evasion . 183
12 Inflammatory Biomarkers for Cancer . 195
13 Tumor Infiltrating Lymphocytes in Breast Cancer: Implementation of a New Histopathological Biomarker . 207
14 Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments . 245
15 The Role of Platelets in the Tumor Microenvironment 267
16 Neurogenesis in the Tumor Microenvironment 283
17 Neuropilins as Cancer Biomarkers: A Focus on Neuronal Origin and Specific Cell Functions 295
18 The Role of AXL Receptor Tyrosine Kinase in Cancer Cell Plasticity and Therapy Resistance . 307
19 Modeling the Tumor Microenvironment in Patient-Derived Xenografts: Challenges and Opportunities . 329
20 Use of Imaging Mass Cytometry in Studies of the Tissue Microenvironment . 345
21 Artificial Intelligence in Studies of Malignant Tumours . 365
• Part II Clinical Applications: Organ Related Studies of Biomarkers and Therapy
22 The Tumor and Its Microenvironment as Complementary Sources of Cancer Biomarkers . 379
23 Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer . 401
24 MR-Derived Biomarkers for Cancer Characterization . 425
25 The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms . 441
26 Models of Tumor Progression in Prostate Cancer 453
27 Prostate Cancer Biomarkers: The Old and the New 467
28 The Role of the Microenvironment in Endometriosis: Parallels and Distinctions to Cancer . 483
29 Tumor-Vascular Interactions in Non-Small Cell Lung Cancer . 497
30 Tumor–Host Interactions in Malignant Gliomas . 509
31 The Role of the Microenvironment in Tumor Promoting Stress Responses 519
32 Vascular Co-option in the Brain Tumor Microenvironment 537
33 Biomarker Panels and Contemporary Practice in Clinical Trials of Personalized Medicine . 549
34 Cancer Biomarkers: A Long and Tortuous Journey 563
Index 581

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed.
Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

Features
• Covers basic model studies of novel biomarkers and treatment targets of the microenvironment
• Explores a variety of different classes of biomarkers in human tumors
• Features new chapters covering the use of artificial intelligence and imaging mass cytometry
• Contains mechanisitic data and information on the latest studies of human tumor tissue