BIOMARKERS OF THE TUMOR MICROENVIRONMENT. BASIC STUDIES AND PRACTICAL APPLICATIONS

1. The Role of the Tumor Microenvironment in Regulating Angiogenesis
2. More Than a Barrier: How the Endothelium Instructs Metastasis
3. Tissue-Based Biomarkers of Tumor-Vascular Interactions
4. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?
5. Stromal PDGF Receptors as Prognostic and Predictive Biomarkers
6. The Function and Diagnostic Potential of Adipocyte-Derived Factors in the Tumor Microenvironment
7. Cancer Immunity and Immune Evasion Mechanisms
8. Drivers of EMT and Immune Evasion
9. Inflammatory Biomarkers for Cancer
10. Immunology of Solid Tumors Beyond Tumor-Infiltrating Lymphocytes: The Role of Tertiary Lymphoid Structures
11. The Role of Platelets in the Tumor Microenvironment
12. Regulation of Tumor Progression and Metastasis by Bone Marrow-Derived Microenvironments
13. Neuropilin 1 and Neuropilin 2: Cancer Progression and Biomarker Analysis
14. The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance
15. Gene Expression Signatures of the Tumor Microenvironment: Relation to Tumor Progress in Breast Cancer
16. MR-Derived Biomarkers for Cancer Characterization
17. The Influence of Tissue Architecture on Drug Response: Anticancer Drug Development in High-Dimensional Combinatorial Microenvironment Platforms
18. Models of Tumor Progression in Prostate Cancer
19. Tumor-Host Interactions in Malignant Gliomas
20. The Tumor Microenvironment in Cutaneous Melanoma: Friend or Foe
21. Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed.
Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Features
• Covers basic model studies of novel biomarkers and treatment targets of the microenvironment, exploration and validation of different classes of biomarkers in human tumors, and challenges of clinical implementation and treatment trials
• High-quality illustrations and colour images of tissue-based biomarkers
• International authors and opinion leaders in different research fields

Authors
• Lars A. Akslen, M.D., Ph.D., Centre for Cancer Biomarkers, Department of Clinical Medicine, The Gade Laboratory for Pathology University of Bergen, NORWAY
• Randolph S. Watnick, Ph.D., Assistant Professor, Department of Surgery, Harvard Medical School, Vascular Biology Program, Boston Children's Hospital Boston, USA