HUMAN REPRODUCTIVE AND PRENATAL GENETICS. 2ND EDITION

Part I. Reproductive Tract Development and Gametogenesis
1. Developmental Genetics of the Male Reproductive System
2. Genetics and genomics of early gonad development
3. Genetics of Meiotic Chromosome Dynamics and Fertility
4. Effects of Aging on Sperm Chromatin
5. In Vitro Spermatogenesis from Pluripotent Stem Cells
6. Developmental Genetics of the Female Reproductive Tract
7. The Molecular Genetics of Oogenesis
8. Epigenetic Control of Oocyte Development
9. RNA Binding Protein Networks and Translational Regulation in Oocytes
10. Translational Regulation of Gene Expression during Oogenesis and Pre-implantation Embryo Development
11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications

Part II. Embryo Implantation, Placenta Development and Pregnancy
12. Transcriptomics of the Human Endometrium and Embryo Implantation
13. Epigenetic Modifications in the Human Placenta
14. microRNAs in pregnancy: implications for basic research and clinical management
15. Chromatin Landscapes and Sex Determination
16. Genetic Alterations of Placental Development and Preeclampsia
17. Genetics and Genomics of Preterm Birth
18. The Intergenerational Effects on Fetal Programming

Part III. Infertility and Assisted Reproductive Technology
19. Genetic Testing in Male Infertility
20. Genetics and Genomics of Endometriosis
21. Genetics and Genomics of Primary Ovarian Insufficiency
22. Genetics of Polycystic Ovary Syndrome
23. Genetics and Genomics of Recurrent Pregnancy Loss
24. Genetic Basis of Metabolism and Inflammation in PCOS
25. Human Genetics and Assisted Reproduction in Endometriosis Uterine Transplantation
26. Microbiota and Human Reproduction

Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening
27. Epidemiology and Genetics of Human Aneuploidy
28. Next Generation Sequencing for Gene Panels and Clinical Exomes
29. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities
30. Noninvasive Prenatal Testing for Genetic Diseases
31. Emerging Planforms for Preimplantationl Genetic Testing
32. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations
33. Prenatal diagnosis and treatment of genetic steroid disorders
34. Maternal Genetic Disorders and Fetal Development
35. Genomic Sequencing for Newborn Screening
36. Implementation of Genomic Medicine in Reproductive, Prenatal and Neonatal health
37. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy
38. Novel Scientific Discoveries in Reproductive and Prenatal Genetics and their Future Applications
39. Ethical Issues Related to Research on Genome Editing in Human Embryos

• Features chapter contributions from leading international scientists and clinicians
• Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more
• Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and -omics-based approaches
• Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Authors
• Peter C.K. Leung, Professor, Department of Obstetrics and Gynecology, University of British Columbia, Canada.
• Jie Qiao, Chief Scientist of the Ministry of Science and Technology of China, the Incumbent Director of the North Third Hospital Department of Obstetrics and Gynecology, the Chinese Medical Association branch chairman for Reproductive Medicine, and the Beijing Medical Association branch chairman for Reproductive Medicine