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Part I. Reproductive Tract Development and Gametogenesis
1. Developmental Genetics of the Male Reproductive System
Dolores Lamb
2. Genetics and genomics of early gonad development
Kai Kei Miu, Dan Dan Cao, Gang Lu and Wai Yee Chan
3. Genetic Analysis of Meiotic Chromosome Dynamics and Fertility
Mary Ann Handel, Travis Kent and Tanmoy Bhattacharyya
4. Aging and Sperm Chromatin Quality
Bernard Robaire, Anais Noblanc and Heather Fice
5. In Vitro Spermatogenesis from Embryonic Stem Cells
Qi Zhou
6. Developmental Genetics of the Female Reproductive Tract
Jose Teixeira and Amanda Patterson
7. Molecular Genetics of Oogenesis
Jie Qiao
8. Epigenetic Control of Oocyte Development
Maria M. Vivieros and Rabindranath de la Fuente
9. RNA Binding Protein Networks and Translational Control in Oocytes
Marco Conti
10. Translational Regulation of Gene Expression During Oogenesis and Pre-Implantation Embryo Development
Emre U. Seli and Ecem Esencan
11. MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications
Allison Tscherner, Leanne Stalker and Jonathan LaMarre
Part II. Embryo Implantation, Placenta Development and Pregnancy
12. Mechanisms of Embryo Implantation and Implantation Failure
Francesco DeMayo
13. Transcriptomics of the Human Endometrium and Embryo Implantation
Carlos Simon and Maria Ruiz
14. Maternal Recognition of Pregnancy
Asgerally T. Fazleabas
15. Human Genetics at the Fetal-Maternal Interface
Claire Trelford Roberts
16. Epigenetic Modifications in the Human Placenta
Wendy P. Robinson
17. Micro RNA in the Human Placenta and Pre-eclampsia
Yan-Ling Wang
18. Genetics and Genomics of Preterm Birth
Stephen J. Lye, Oksana Shynlova and Lubna Nadeem
19. The Intergenerational Effects on Fetal Programming
He-Feng Huang
Part III. Infertility and Assisted Reproductive Technology
20. Genetic Testing in Male Infertility
Alberto Ferlin and Carlo Foresta
21. Genetics and Genomics of Endometriosis
Linda C. Giudice
22. Genetics and Genomics of Primary Ovarian Insufficiency
Elena J. Tucker, Sylvie Jaillard and Andrew H. Sinclair
23. Genetics of Polycystic Ovary Syndrome
Tristan Hardy and Robert J. Norman
24. Genetics and Genomics of Recurrent Pregnancy Loss
Laura Kasak, Kristiina Rull and Maris Laan
25. Human Genetics and Assisted Reproduction
Chii-Ruey Tzeng
26. Uterine Transplantation
Mats Brännström
Part IV. Preimplantation/Prenatal Genetic Diagnosis and Screening
27. Preimplantation Genetic Diagnosis (PGD) and Screening (PGS)
Alan H. Handyside
28. Molecular Genetics in Preimplantation Diagnosis and Screening
Joris R. Vermeesch
29. Epidemiology and Genetics of Human Aneuploidy
Howard Cuckle and Svetlana Arbuzova
30. Next Generation Sequencing for Gene Panels and Clinical Exomes
Ignatia Barbara Van den Veyver
31. Chromosomal Microarrays and Exome Sequencing for Diagnosis of Fetal Abnormalities
Brynn Levy
32. Noninvasive Prenatal Testing for Genetic Diseases
Jason C.H. Tsang and Y.M. Dennis Lo
33. Non-Invasive Prenatal Testing by Cell-Free DNA: Technology, Biology, Clinical Utility and Limitations
Francesca Romana Grati, Komal Bajaj, Giuseppe Simoni, Federico Maggi, Susan J. Gross and Jose Carlos Pinto B. Ferreira
34. Prenatal diagnosis and treatment of genetic steroid disorders
Maria I. New and Ahmed A. Khattab
35. Application of Gene-Editing Technologies in Embryos and Their Potential for Gene Therapy
Cristina Eguizabal, Nuria Montserrat and Juan Carlos Izpisua Belmonte

• Features chapter contributions from leading international scientists and clinicians
• Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization and implantation, in vitro culture of the human embryo for the study of post-implantation development, and more
• Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and -omics based approaches

• Peter C. K. Leung, Professor, Department of Obstetrics and Gynecology, University of British Columbia, Canada.
• Jie Qiao, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Beijing University Third Hospital, Haidian District, Beijing, China

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